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Talk: AMPA-receptors and fast synaptic transmission in the... (36 min)

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DETAILED SLIDE INDEX

  1. 1. Introduction
  2. 2. Talk topics
  3. 3. Question 1
  4. 4. Excitatory central synapse
  5. 5. Glutamate as a neurotransmitter - history
  6. 6. Postsynaptic AMPA- and NMDA receptors (1)
  7. 7. Postsynaptic AMPA- and NMDA receptors (2)
  8. 8. Question 2
  9. 9. Ionotropic glutamate receptor subunits
  10. 10. AMPAR subunit topology
  11. 11. Glutamate receptors & K+ channels homology
  12. 12. AMPAR-subunits edited residues & splice variants
  13. 13. Question 3
  14. 14. Distribution and plasticity of AMPAR subunits
  15. 15. Three types of change in AMPARs
  16. 16. Implications on synaptic transmission
  17. 17. Effect of editing on AMPAR subunits
  18. 18. ‘Flip’ and ‘flop’ and AMPAR desensitisation
  19. 19. Desensitisation of heteromeric AMPARs
  20. 20. Main message
  21. 21. Question 4
  22. 22. How transmitter molecules open channels
  23. 23. AMPAR gating mechanism
  24. 24. Channel conductance & agonist binding sites
  25. 25. Question 5
  26. 26. Auxiliary transmembrane AMPAR subunit proteins
  27. 27. Stargazin alters AMPAR functional properties
  28. 28. Variety of auxiliary AMPAR regulatory proteins
  29. 29. Acknowledgements and thanks
  30. 30. END

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TALK'S CITATION

Cull-Candy, S. (2015), "AMPA-receptors and fast synaptic transmission in the brain", in Cull-Candy, S. (ed.), Synapses, Neurotransmitters and Receptor Channels, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1803796)

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ABOUT THIS TALK

Speaker(s)

Prof. Stuart Cull-Candy Show Biography

SPEAKER BIOGRAPHY

Prof. Stuart Cull-Candy – University College London, UK

Stuart Graham Cull-Candy is a British neuroscientist. He holds the Gaddum Chair of Pharmacology and a personal Chair in Neuroscience at University College London. He is also a member of the Faculty of 1000 and holds a Royal Society - Wolfson Research position. He has been an Editorial Advisor to Nature, and served on the Editorial Boards of various journals including Neuron, The Journal of Physiology and as a Reviewing Editor on Journal of Neuroscience. Currently he is a member of the Royal Society's University Research Fellowships Committee, and the Leverhulme Trust Senior Research Fellowships panel. He was awarded the GL Brown Prize by the UK Physiological Society, and was appointed a Howard Hughes International Scholar in 1993 (one of only 20 in the UK). He is a Fellow of the Royal Society, the Academy of Medical Sciences and the British Pharmacological Society.

Publication Date

January, 2015

Topics Covered

The fast component of excitatory synaptic transmission in the brain mediated by AMPARs... more

TOPICS COVERED IN THIS TALK

  • The fast component of excitatory synaptic transmission in the brain mediated by AMPARs
  • Functionally distinct AMPAR subtypes are involved in transmission (importance of topology)
  • How AMPAR diversity shapes transmission (implications of differential distribution and plasticity)
  • How AMPAR structure affects its behaviour and properties
  • Role of auxiliary AMPAR proteins (stargazin) in controlling AMPAR properties and diversity

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