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0:00
I'm
professor Mary Reilly.
I am head of the Peripheral
Nerve Section of the MRC Center
for Neuromuscular Diseases in the
UCL Institute of Neurology, London.
And today I'm going to talk
about inherited neuropathies.
0:15
So the content of
this lecture will be
divided into two overall portions.
The first is to define what I
mean by inherited neuropathies.
And the second is to show an
approach to diagnosis which would
encapsulate the clinical features,
pathogenesis, and what we
understand about
inherited neuropathies.
0:35
First of all, I'd
like to just remind
you what we are talking about.
We're talking about the peripheral
nervous system, which is not
the brain or the spinal cord, which
is the central nervous system.
The peripheral nervous system
includes the nerves in the arms
and the legs which are divided
into motor nerves, which travel
from the spinal cord to the
muscles and make muscles move,
and the sensory nerves where
people touch things and the touch
sensation or other
sensations go from the limbs
back up to the spinal cord.
1:06
This is a cartoon of
a peripheral nerve.
As you will see, the nerve contains
fascias, and in these fascias
there are individual bundles of
nerves separated from each other
by connective tissue
and by blood vessels.
1:22
This is an example of a human
normal peripheral nerve,
which is biopsied
from a sural nerve.
In this, you can
see like the cartoon
that we have a number of fascias.
And in between the
fascias, connective
tissue and blood vessels.
1:38
This is a higher magnification
of the same nerve.
And now you begin to see
the individual nerve fibers.
What you can see is the pain
center which is the axon
and this is surrounded by the darker
staining material which is myelin.
These fibers are
myelinated nerve fibers.
We'll also see some very
small myelinated nerve fibers.
