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0:00
Hello.
My name is Hironobu Fujiwara.
I am currently studying
at the RIKEN Center
for Developmental
Biology in Kobe, Japan.
Today I'd like to talk about
several of the extracellular
matrices, ECM in mammalian skin.
0:18
Here is outline of my talk.
First, I'll explain
the general importance
and function of
cell-ECM interactions.
Second, I'll talk about the skin
ECM, which comprises a basement
membrane and interstitial matrix.
Third, skin ECM heterogeneity.
Fourth, ECM-integrin interactions
in epidermal stem cell regulation.
And fifth, non-cell-autonomous
functions of the skin ECM.
I'll then move on to
the role of the ECM
in aging and associated
pathological conditions,
followed by perspectives.
0:56
First, I'll talk about
the general importance
and function of
cell-ECM interactions.
1:04
During the developmental of
complex multicellular organs,
including the skin, stem,
or progenitor cells,
differentiate into
distinct cell types.
These cells aggregate into
tissues where they are positioned
in the current place,
and simultaneously
engage in appropriate
cellular interactions.
As a result, the
integrated cells establish
emergent properties of
a complex organ system.
Scientists have long been
investigating the formation
of such multicellular assemblies and
the mechanisms that keep the cells
in their proper
place and enable them
to develop communication networks.
