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Talk: Innate-like B cells (50 min)

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X Navigable Slide Index
  1. Introduction
  2. Introduction to B cells
  3. Innate-like B cells (1)
  4. Innate-like B cells (2)
  5. Innate and adaptive mechanisms
  6. Innate-like B cells are similar to innate-like T cells
  7. Mouse B-1 cells
  8. The origin and maturation of B cells
  9. T cell dependent antibody responses
  10. Germinal centers
  11. Innate-like B cells have multiple characteristics
  12. Characteristics of Innate-like B cells
  13. Molecular targets of the innate immune system
  14. B1a antibody response to phosphorylcholine (PC)
  15. PC is a major component of organisms
  16. B1a subset
  17. Development of innate-like lymphocytes
  18. TEPC15Id expressing B cells (1)
  19. TEPC15Id expressing B cells (2)
  20. Some clones depend on TdT activity
  21. B1B + MZ
  22. Low affinity and high avidity antibodies
  23. Conserved antigens on a variety of organisms
  24. Chitin
  25. Monoclonal antibodies to GlcNAc bind chitin
  26. Alpha 1-3 glucans
  27. Sialyl-lacto-N-tetraose
  28. Antibodies to Aspergillus fumigatus
  29. The spleen: largest encapsulated lymph organ
  30. Special characteristics of the spleen
  31. Association between asplenia and OPSI
  32. A ruptured spleen is very dangerous
  33. The marginal zone forms an interface
  34. Anatomy of the mouse spleen
  35. Histological analysis of the mouse spleen
  36. Fluorescent-labeled bacteria to mouse spleen
  37. MZ B cells respond to blood-borne organisms
  38. Immune response in anti-PC Tg mice
  39. Innate-like B cells and protection against infection
  40. Human innate-like B cells
  41. Innate-like B cell derived antibodies: self-reactive
  42. Why these clones react to self antigens
  43. Functions of innate B cells and their products
  44. Summary
  45. Acknowledgements
  46. END
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DETAILED SLIDE INDEX

  1. 1. Introduction
  2. 2. Introduction to B cells
  3. 3. Innate-like B cells (1)
  4. 4. Innate-like B cells (2)
  5. 5. Innate and adaptive mechanisms
  6. 6. Innate-like B cells are similar to innate-like T cells
  7. 7. Mouse B-1 cells
  8. 8. The origin and maturation of B cells
  9. 9. T cell dependent antibody responses
  10. 10. Germinal centers
  11. 11. Innate-like B cells have multiple characteristics
  12. 12. Characteristics of Innate-like B cells
  13. 13. Molecular targets of the innate immune system
  14. 14. B1a antibody response to phosphorylcholine (PC)
  15. 15. PC is a major component of organisms
  16. 16. B1a subset
  17. 17. Development of innate-like lymphocytes
  18. 18. TEPC15Id expressing B cells (1)
  19. 19. TEPC15Id expressing B cells (2)
  20. 20. Some clones depend on TdT activity
  21. 21. B1B + MZ
  22. 22. Low affinity and high avidity antibodies
  23. 23. Conserved antigens on a variety of organisms
  24. 24. Chitin
  25. 25. Monoclonal antibodies to GlcNAc bind chitin
  26. 26. Alpha 1-3 glucans
  27. 27. Sialyl-lacto-N-tetraose
  28. 28. Antibodies to Aspergillus fumigatus
  29. 29. The spleen: largest encapsulated lymph organ
  30. 30. Special characteristics of the spleen
  31. 31. Association between asplenia and OPSI
  32. 32. A ruptured spleen is very dangerous
  33. 33. The marginal zone forms an interface
  34. 34. Anatomy of the mouse spleen
  35. 35. Histological analysis of the mouse spleen
  36. 36. Fluorescent-labeled bacteria to mouse spleen
  37. 37. MZ B cells respond to blood-borne organisms
  38. 38. Immune response in anti-PC Tg mice
  39. 39. Innate-like B cells and protection against infection
  40. 40. Human innate-like B cells
  41. 41. Innate-like B cell derived antibodies: self-reactive
  42. 42. Why these clones react to self antigens
  43. 43. Functions of innate B cells and their products
  44. 44. Summary
  45. 45. Acknowledgements
  46. 46. END

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TALK'S CITATION

Kearney, J.F. (2012), "Innate-like B cells", in Gordon, S. (ed.), Cells of the Innate Immune System: Roles in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1463241)

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ABOUT THIS TALK

Speaker(s)

Prof. John F. Kearney Show Biography

SPEAKER BIOGRAPHY

Prof. John F. Kearney – University of Alabama, USA

John F Kearney is Professor of Microbiology at the University of Alabama at Birmingham, Alabama. He obtained his PhD at Melbourne University, Australia and has been a Faculty member at UAB since 1978. John Kearney studies various aspects of B cell development and function. Particular emphasis is placed on acquisition of the B cell repertoire during early life, the function of B cell subsets including Innate-like B cells and the role of B cells and antibodies in Asthma and Type 1 Diabetes.

Publication Date

April, 2012

Topics Covered

Introduction to B cells... more

TOPICS COVERED IN THIS TALK

  • Introduction to B cells
  • Innate-like B cells
  • Origin and function of innate-like B cells
  • Targets of Innate-like B cell derived antibody
  • Anatomy of Innate-B cell organ distribution
  • Human Innate-like B cells and possible clinical applications

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TOPICS COVERED IN THIS TALK

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TOPICS COVERED IN THIS TALK

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