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Navigable Slide Index

1. Introduction
2. Overview of presentation
3. Chronic diseases distribution and income
4. The worldwide prevalence of asthma
5. Disparities of common disease prevalence
6. The impact of ethnicity on disease severity
7. Genetics for the human race
8. Health disparities: a role for genetics?
9. Complex traits defined: genetic heterogeneity
10. Monogenic vs. complex traits
11. Concordance for atopic disease in twins (1)
12. Asthma genes so far
13. Concordance for atopic disease in twins (2)
14. Complex traits defined: the environment
15. Genes and the environment: trait development
16. Genes and the environment: the Australia study
17. Gene by environment interaction
18. Asthma and the Papua New Guinea story
19. House dust mites up close
20. Cockroach: another major allergen
21. Environment or ethnicity?
22. Health and the human condition: biogeography
23. Ancient diseases
24. Diseases of city-state societies
25. Immune pathways
26. Genes and environment
27. The hygiene hypothesis
28. The hygiene hypothesis tested
29. The Barbados asthma genetics study
30. Comparison of house dust endotoxin surveys
31. CD14: a major innate immunity player
32. CD14 C\T polymorphism and allergic disease
33. Family-based studies of CD14 C\T and asthma
34. Gene-environment interaction and CD14 alleles
35. Frequency of the CD14-260 C\T allele
36. Study on sepsis-associated acute lung injury
37. Survival of sepsis-associated ALI in two groups
38. CD14 C\T allele protects from ALI mortality
39. Possible selective advantage to C allele
40. Serum IgE levels in parasitic disease and asthma
41. Total IgE and response to S. mansoni infection
42. Amino acid sequence alignments of tropomyosin
43. Relationship between parsitic disease and allergy
44. Total serum IgE levels in two populations
45. Linkage studies in parasitic disease and asthma
46. Alleles associated with parasitic disease\asthma
47. Common variant/multiple disease hypothesis
48. Clusters of loci across linkage studies
49. The genetic association database
50. CV/MD hypothesis: asthma and ALI
51. Pathogens and host counter-adaptations: Duffy
52. Frequencies of Duffy positive genotype
53. Duffy antigen/receptor for chemokines (DARC)
54. Family-based studies on DARC and asthma
55. Summary
56. Acknowledgments

Topics Covered

• Genetic epidemiology of common, complex and chronic diseases
• Evidence of a role for a genetic basis of health disparities
• Genetic studies on asthma and allergic disease and ethnicity
• Geneenvironment interactions
• Biogeography and the hygiene hypothesis
• Innate vs. adaptive immunity and the common variant/multiple disease hypothesis
• Antagonistic pleiotropy

Links

Series:

• Evolution and Medicine

Categories:

• Clinical Practice
• Genetics & Epigenetics

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Barnes, K. (2007, October 1). Health disparities in common complex diseases: a role for genetics? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/133/.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Kathleen Barnes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.