Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Proximal causes of disease
3. Proximate vs. ultimate causes of disease
4. Most common causes of death (U.S. 2002)
5. Assessment of the genetics effect on disease risk
6. Relative risks for common diseases in sibs
7. Relative risks for rare diseases in sibs
8. Fitness
9. Why genetic disease?
10. Why are'nt organisms optimal?
11. How natural selection alone creates disease
12. Heterozygote advantage in HLAs
13. HLAs heterozygote advantage for AIDS
14. Balancing natural selection - summary
15. Survival and aging in hunter-gatherers
16. Reproduction and aging in hunter-gatherers
17. Age-related evolutionary tradeoffs
18. Maintenance of variation by evolutionary tradeoffs
19. Mutation rate
20. Genomic mutation rate
21. Mutation-selection balance
22. All mutations cost the population
23. Deleterious mutations at APC
24. Mutation-selection balance explains APC
25. The effect of deleterious mutations
26. Genetic disease and mutation-selection balance
27. The idea of evolutionary lag
28. Changes in the human environment
29. Diseases of civilization
30. Evolutionary lag and disease
31. Gene flow and genotype-environment interaction
32. Example: sickle-cell anemia
33. Coevolutionary arms races
34. HLA and coevolutionary arms race
35. Response of HIV to HLA variation
36. Variation in malaria affects susceptibility
37. APOE and GXE interactions
38. Epistasis and GXE interactions
39. Genotype-environment interaction: summary (1)
40. Genotype-environment interaction: summary (2)
41. Unsolved problems
42. Why does the evolutionary explanation matter?
43. Optimism vs. pessimism

Topics Covered

• Proximal vs. ultimate causation
• Causes of death in modern societies
• Quantifying genetic causation
• Relative risks of common diseases
• Fitness
• Why do genetic diseases exist?
• Selection can maintain disease
• Mutation-selection balance
• Evolutionary lag
• Gene flow and genotypeenvironment interactions
• Co-evolutionary arms races
• Why evolution matters

Links

Series:

• Evolution and Medicine

Categories:

• Genetics & Epigenetics

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on August 16, 2020

Financial Disclosures

• Dr. David Houle has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.