Printable Handouts

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Navigable Slide Index

1. Introduction
2. 'Sugar' roles & codes
3. 'Sugar' therapeutics
4. Drug needs and issues
5. Market needs and issues (1)
6. Market needs and issues (2)
7. Background - Heparosan? (1)
8. Background - Heparosan? (2)
9. Technology
10. Technology - stealth rationale
11. Structure of Heparan Sulfate
12. Advantages over PEG - bio-inert
13. Advantages over PEG - bio-stealthy
14. Advantages over PEG - bio-compatible
15. Heparosan as a drug delivery vehicle
16. Technology overview: PmHS1
17. Technology overview - polymer production
18. Synthesis of monodisperse Heparosan polymers
19. Cargo-coupling chemistries include
20. Technology - animal studies
21. Technology - half-life study
22. Technology - drug stability
23. Technology - no accumulation in organs
24. Technology - safe degradation
25. Technology - cargo coupling
26. Technology - cargo coupling via sulhydryls
27. Technology - activity of HEP-G-CSF
28. Technology - Heparosan toxicology (1)
29. Technology - Heparosan toxicology (2)
30. Technology - summary
31. Value proposition
32. Acknowledgements

Topics Covered

• Drug Delivery Vehicles
• Use of stealthy polymers to improve drug cargo pharmacokinetics and fate in the body
• Glycosaminoglycan [GAG] Glycosyltransferases
• Bifunctional synthases polymerize sugar chains
• Chemoenzymatic synthesis; use of enzymes to create defined polymers

Links

Series:

• Glycobiology

Categories:

• Biochemistry
• Cell Biology
• Pharmaceutical Sciences

Talk Citation

DeAngelis, P.L. (2012, November 27). Use of heparosan polysaccharide to enhance drug delivery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 31, 2024, from https://doi.org/10.69645/GDUJ1252.
Export Citation (RIS)

Publication History

• Published on November 27, 2012

Financial Disclosures

• Prof. Paul L. DeAngelis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.