Natural Killer Cell Biology:

Prof. Lewis Lanier - University of California, San Francisco, USA

Lewis Lanier is an American Cancer Society Research Professor and Professor and Vice Chair, Department of Microbiology & Immunology at the University of California, San Francisco, USA. His laboratory research focuses on the human and mouse activating and inhibitory receptors that are predominantly expressed by Natural Killer (NK) cells, but are also present on subsets of effector/memory T cells and some myeloid cells. He is particularly interested in the activating NK receptors that signal by associating with two distinct signaling adapter proteins named DAP10 and DAP12. The goal of his research is to understand the role of these NK cell receptors in immune defense against tumors and microbial pathogens, and explore their potential detrimental role in autoimmune diseases.