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The Cell Division Cycle: Controlling when and where cells divide and differentiate
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The Cell Division Cycle - sample extracts available

The Cell Division Cycle:

Controlling when and where cells divide and differentiate

    TARGET AUDIENCE

For all those wishing to be briefed on the fundamentals and the latest developments in the study and understanding of the cell division cycle including students of graduate courses in biochemistry, cell biology, cancer, immunology and developmental biology, advanced medical students particularly those specializing in oncology, academic researchers interested in proliferative diseases, as well as researchers in the pharmaceutical industry.


    SERIES EDITOR(S)

Prof. Jonathan Millar - University of Warwick, UK

Jonathan Millar is a Professor in the Cell Cycle Control Laboratory at the University of Warwick, UK. His laboratory is primarily interested in the molecular mechanisms that ensure the faithful separation of sister chromatids in eukaryotic cells. He is also interested in the signaling mechanisms by which external cues such as nutrient limitation, environmental stress and mating pheromone are perceived by the cell and how these factors influence cell cycle progression.


Series Online Publication: Apr 2009



     Co-ordination of G1 Progression

START control in yeast - play sample talk extractSTART control in yeast - view talk information

1. START control in yeast (37 mins)
Prof. Curt Wittenberg - The Scripps Research Institute, USA

The pRB/E2F pathway - play sample talk extractThe pRB/E2F pathway - view talk information

2. The pRB/E2F pathway (33 mins)
Prof. Jacqueline Lees - Massachusetts Institute of Technology, USA

Cell cycle control by the ubiquitin system in mammals - play sample talk extractCell cycle control by the ubiquitin system in mammals - view talk information

3. Cell cycle control by the ubiquitin system in mammals (35 mins)
Prof. Michele Pagano - New York University Cancer Institute and the Howard Hughes Medical Institute, USA

     Chromosome Duplication

Replication licensing - play sample talk extractReplication licensing - view talk information

4. Replication licensing (47 mins)
Prof. Julian Blow - Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, UK

Initiation of DNA replication - play sample talk extractInitiation of DNA replication - view talk information

5. Initiation of DNA replication (51 mins)
Prof. Bruce Stillman - Cold Spring Harbour Laboratory, USA

Regulation of replication fork progression and stability - play sample talk extractRegulation of replication fork progression and stability - view talk information

6. Regulation of replication fork progression and stability (48 mins)
Dr. Luis Aragón - Medical Research Council, Imperial College London, UK

Nucleosome assembly during DNA replication - play sample talk extractNucleosome assembly during DNA replication - view talk information

7. Nucleosome assembly during DNA replication (35 mins)
Dr. Alain Verreault - University of Montreal, Canada

     Preparing for Mitosis

Sister chromatid cohesion: simple concept, complex reality - play sample talk extractSister chromatid cohesion: simple concept, complex reality - view talk information

8. Sister chromatid cohesion: simple concept, complex reality (27 mins)
Prof. Douglas Koshland - Carnegie Institute of Sciences and the Howard Hughes Medical Institute, USA

Mitotic chromosome condensation - play sample talk extractMitotic chromosome condensation - view talk information

9. Mitotic chromosome condensation (50 mins)
Prof. Andrew Belmont - University of Illinois at Urbana-Champaign, USA

Centrosome duplication and separation in animal cells - play sample talk extractCentrosome duplication and separation in animal cells - view talk information

10. Centrosome duplication and separation in animal cells (33 mins)
Prof. Andrew Fry - University of Leicester, UK

     Spindle Assembly and Chromosome Segregation

Bipolar spindle assembly - play sample talk extractBipolar spindle assembly - view talk information

11. Bipolar spindle assembly (30 mins)
Dr. Eric Karsenti - EMBL, Heidelberg, Germany

Chromosome biorientation in yeast - play sample talk extractChromosome biorientation in yeast - view talk information

12. Chromosome biorientation in yeast (54 mins)
Prof. Mike Stark - University of Dundee, UK

Regulation of mammalian cell division by the chromosomal passenger complex - play sample talk extractRegulation of mammalian cell division by the chromosomal passenger complex - view talk information

13. Regulation of mammalian cell division by the chromosomal passenger complex (43 mins)
Dr. Susanne Lens - University Medical Centre Utrecht, The Netherlands

     Mitotic Exit and Cytokinesis

     Checkpoints Governing Cell Cycle Progression

The DNA damage response - play sample talk extractThe DNA damage response - view talk information

15. The DNA damage response (34 mins)
Dr. Vincenzo Costanzo - Cancer Research UK, UK

The spindle checkpoint - play sample talk extractThe spindle checkpoint - view talk information

16. The spindle checkpoint (54 mins)
Dr. Kevin Hardwick - University of Edinburgh, UK

Spindle movement and checkpoint control during mitosis in yeast - play sample talk extractSpindle movement and checkpoint control during mitosis in yeast - view talk information

17. Spindle movement and checkpoint control during mitosis in yeast (27 mins)
Prof. John Cooper - Washington University Medical School in St. Louis, USA

The G2/M transition - play sample talk extractThe G2/M transition - view talk information

18. The G2/M transition (43 mins)
Prof. Dr. René Medema - University Medical Center Utrecht, The Netherlands

     The Cell Cycle in Development and Cancer

Mouse models to investigate cell cycle and cancer - play sample talk extractMouse models to investigate cell cycle and cancer - view talk information

19. Mouse models to investigate cell cycle and cancer (62 mins)
Dr. Philipp Kaldis - Institute of Molecular and Cell Biology, Singapore

Drug discovery and target validation in the p53 pathway - play sample talk extractDrug discovery and target validation in the p53 pathway - view talk information

21. Drug discovery and target validation in the p53 pathway (40 mins)
Prof. Sir David Lane - University of Dundee, UK and Institute of Molecular and Cell Biology, Singapore

Role and regulation of Cdk inhibitors in development and cancer - play sample talk extractRole and regulation of Cdk inhibitors in development and cancer - view talk information

22. Role and regulation of Cdk inhibitors in development and cancer (30 mins)
Prof. Martine Roussel - St. Jude Children’s Research Hospital, USA

     Meiosis: A Specialized Cell Cycle

Recombination and the formation of chiasmata in meiosis - play sample talk extractRecombination and the formation of chiasmata in meiosis - view talk information

24. Recombination and the formation of chiasmata in meiosis (58 mins)
Prof. Matthew Whitby - University of Oxford, UK

Geometric regulation of kinetochore orientation - play sample talk extractGeometric regulation of kinetochore orientation - view talk information

25. Geometric regulation of kinetochore orientation (24 mins)
Prof. Yoshinori Watanabe - Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan