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Protein Epidemiology: Understanding Human Diseases at the Level of Protein Structure and Function
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Protein Epidemiology - sample extracts available

Protein Epidemiology:

Understanding Human Diseases at the Level of Protein Structure and Function

    TARGET AUDIENCE

For all those wishing to be briefed on the latest developments in the study and understanding of protein epidemiology including students of graduate courses in the fields of biomedicine, chemical biology, biophysics and agricultural biotechnology, researchers in academic departments who wish to be kept abreast of the latest developments in these areas and scientists in pharmaceutical companies investigating novel targets for drug development.


    SERIES EDITOR(S)

Prof. Ben Dunn - Distinguished Professor of Biochemistry and Molecular Biology, University of Florida, USA

Ben Dunn is a Distinguished Professor of Biochemistry and Molecular Biology at the University of Florida, USA. He received his PhD from the University of California at Santa Barbara. His research focuses on understanding the forces which control the specificity and catalytic efficiency of enzymes. His laboratory studies the proteolytic enzymes through the use of site-directed mutagenesis and kinetic analysis with welldefined synthetic oligopeptide substrates. He is the Editor-in-Chief of Protein and Peptide Letters and Co-Editor of Current Protocols in Protein Science.


Series Online Publication: Oct 2007



     Introduction to Protein Structure and Function

Protein Crystallography - play sample talk extractProtein Crystallography - view talk information

1. Protein Crystallography (33 mins)
Prof. Michael James - University of Alberta, Canada

Kinetic Analysis of Protein Activity - play sample talk extractKinetic Analysis of Protein Activity - view talk information

2. Kinetic Analysis of Protein Activity (48 mins)
Prof. Antonio Baici - University of Zurich, Switzerland

     Creation of Protein Variability by Manipulation of Genes

Perspectives in Biological Catalysis - play sample talk extractPerspectives in Biological Catalysis - view talk information

4. Perspectives in Biological Catalysis (74 mins)
Prof. Stephen Benkovic - The Pennsylvania State University, USA

Fundamentals and Principles for Engineering Proteolytic Activity - play sample talk extractFundamentals and Principles for Engineering Proteolytic Activity - view talk information

5. Fundamentals and Principles for Engineering Proteolytic Activity (45 mins)
Prof. Charles Craik - University of California, San Francisco, USA

     Metabolic Diseases Caused by Genetic Mutation

Modifications of Pyruvate Handling in Health and Disease - play sample talk extractModifications of Pyruvate Handling in Health and Disease - view talk information

6. Modifications of Pyruvate Handling in Health and Disease (36 mins)
Prof. Mary Sugden - Barts and the London School of Medicine and Dentistry, UK

Mitochondrial Fatty Acid Oxidation Deficiencies - play sample talk extractMitochondrial Fatty Acid Oxidation Deficiencies - view talk information

7. Mitochondrial Fatty Acid Oxidation Deficiencies (29 mins)
Prof. Niels Gregersen - University of Aarhus, Denmark

Inborn Errors of Ketone Body Metabolism - play sample talk extractInborn Errors of Ketone Body Metabolism - view talk information

8. Inborn Errors of Ketone Body Metabolism (44 mins)
Dr. Toshiyuki Fukao - Gifu University, Japan

Cathepsin K in Bone and Joint Diseases - play sample talk extractCathepsin K in Bone and Joint Diseases - view talk information

10. Cathepsin K in Bone and Joint Diseases (34 mins)
Prof. Dieter Bromme - University of British Columbia, Canada

Metachromatic Leukodystrophy - play sample talk extractMetachromatic Leukodystrophy - view talk information

11. Metachromatic Leukodystrophy (49 mins)
Prof. Volkmar Gieselmann - Institut fur Physiologische Chemie, University of Bonn, Germany

Fabry Disease: alfa-Galactosidase A Deficiency and Enzyme Replacement Therapy - play sample talk extractFabry Disease: alfa-Galactosidase A Deficiency and Enzyme Replacement Therapy - view talk information

12. Fabry Disease: alfa-Galactosidase A Deficiency and Enzyme Replacement Therapy (22 mins)
Prof. David Warnock - University of Alabama at Birmingham, USA

Acid beta-Glucosidase/Glucocerebrosidase (GCase) - play sample talk extractAcid beta-Glucosidase/Glucocerebrosidase (GCase) - view talk information

13. Acid beta-Glucosidase/Glucocerebrosidase (GCase) (44 mins)
Prof. Gregory Grabowski - Cincinnati Children's Hospital Medical Center, USA

GM2 Gangliosidoses - play sample talk extractGM2 Gangliosidoses - view talk information

14. GM2 Gangliosidoses (39 mins)
Prof. Don Mahuran - The Hospital for Sick Children and the University of Toronto, Canada

The Neuronal Ceroid Lipofuscinoses - play sample talk extractThe Neuronal Ceroid Lipofuscinoses - view talk information

15. The Neuronal Ceroid Lipofuscinoses (27 mins)
Prof. Sandra Hofmann - University of Texas Southwestern Medical Center at Dallas, USA

     Disorders of Blood Coagulation

Tissue Factor and Factor VII: Initiation of Blood Coagulation - play sample talk extractTissue Factor and Factor VII: Initiation of Blood Coagulation - view talk information

16. Tissue Factor and Factor VII: Initiation of Blood Coagulation (26 mins)
Dr. John McVey - MRC Clinical Sciences Centre, Imperial College London, UK

Structure of Thrombin, a Janus-Headed Proteinase - play sample talk extractStructure of Thrombin, a Janus-Headed Proteinase - view talk information

17. Structure of Thrombin, a Janus-Headed Proteinase (36 mins)
Prof. Wolfram Bode - Max-Planck Institute of Biochemistry, Germany

The Protein C-Thrombomodulin Mechanism: Regulating Multiple Biological Systems - play sample talk extractThe Protein C-Thrombomodulin Mechanism: Regulating Multiple Biological Systems - view talk information

18. The Protein C-Thrombomodulin Mechanism: Regulating Multiple Biological Systems (45 mins)
Prof. Edward Conway - Center for Transgene Technology and Therapy, University of Leuven, Belgium

Fibrinogen and Factor XIII - play sample talk extractFibrinogen and Factor XIII - view talk information

19. Fibrinogen and Factor XIII (40 mins)
Prof. John Weisel - University of Pennsylvania School of Medicine, USA

Factor VIII and Haemophilia A - play sample talk extractFactor VIII and Haemophilia A - view talk information

20. Factor VIII and Haemophilia A (32 mins)
Dr. Geoffrey Kemball-Cook - MRC Clinical Sciences Centre, Imperial College London, UK

Factor IX - play sample talk extractFactor IX - view talk information

21. Factor IX (34 mins)
Prof. Bruce Furie - Harvard Medical School, USA

The Biology and Pathobiology of von Willebrand Factor - play sample talk extractThe Biology and Pathobiology of von Willebrand Factor - view talk information

22. The Biology and Pathobiology of von Willebrand Factor (42 mins)
Prof. David Lillicrap - Queen's University, Canada

Idiopathic Thrombocytopenic Purpura - play sample talk extractIdiopathic Thrombocytopenic Purpura - view talk information

23. Idiopathic Thrombocytopenic Purpura (40 mins)
Prof. J. Evan Sadler - Washington University in St. Louis, USA

The Physiology and Pathology of Coagulation Factor XI - play sample talk extractThe Physiology and Pathology of Coagulation Factor XI - view talk information

24. The Physiology and Pathology of Coagulation Factor XI (40 mins)
Dr. David Gailani - Vanderbilt University, USA

Regulation of Blood Coagulation by the Serpin, Antithrombin - play sample talk extractRegulation of Blood Coagulation by the Serpin, Antithrombin - view talk information

25. Regulation of Blood Coagulation by the Serpin, Antithrombin (48 mins)
Prof. Steve Olson - University of Illinois at Chicago, USA

Fibrinolysis - play sample talk extractFibrinolysis - view talk information

26. Fibrinolysis (26 mins)
Prof. Edward Tuddenham - Royal Free Hospital and University College Medical School, UK

     Other Molecular and Metabolic Disorders

Glucose-6-Phosphate Dehydrogenase Deficiency - play sample talk extractGlucose-6-Phosphate Dehydrogenase Deficiency - view talk information

27. Glucose-6-Phosphate Dehydrogenase Deficiency (45 mins)
Dr. Jane Leopold - Brigham and Women's Hospital, Harvard Medical School, USA

Pleiotropic and Epistatic Genes in Sickle Cell Anaemia - play sample talk extractPleiotropic and Epistatic Genes in Sickle Cell Anaemia - view talk information

29. Pleiotropic and Epistatic Genes in Sickle Cell Anaemia (39 mins)
Prof. Ronald Nagel - Albert Einstein College of Medicine, USA

Pyruvate Kinase Deficiency - play sample talk extractPyruvate Kinase Deficiency - view talk information

30. Pyruvate Kinase Deficiency (38 mins)
Prof. Alberto Zanella - Fondazione IRCCS Ospedale Maggiore Policlinico, Italy

Heritable Disorders of Collagen - play sample talk extractHeritable Disorders of Collagen - view talk information

31. Heritable Disorders of Collagen (46 mins)
Dr. Heather Yeowell - Duke University Medical Center, USA

Genetic Disorders of Carbonic Anhydrases II and IV - play sample talk extractGenetic Disorders of Carbonic Anhydrases II and IV - view talk information

32. Genetic Disorders of Carbonic Anhydrases II and IV (44 mins)
Prof. William Sly - St. Louis University School of Medicine, USA

Duchenne Muscular Dystrophy - play sample talk extractDuchenne Muscular Dystrophy - view talk information

33. Duchenne Muscular Dystrophy (40 mins)
Prof. Jeff Chamberlain - University of Washington, USA

Serpins and Serpinopathies - play sample talk extractSerpins and Serpinopathies - view talk information

34. Serpins and Serpinopathies (21 mins)
Dr. James Whisstock - Monash University, Australia

Rhodopsin and Retinitis Pigmentosa - play sample talk extractRhodopsin and Retinitis Pigmentosa - view talk information

35. Rhodopsin and Retinitis Pigmentosa (37 mins)
Dr. Shalesh Kaushal - University of Florida, USA