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The Mechanisms of Ribosome Function: Insights into protein synthesis
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The Mechanisms of Ribosome Function - sample extracts available

The Mechanisms of Ribosome Function:

Insights into protein synthesis

    TARGET AUDIENCE

For all those wishing to be briefed on the latest developments in the study and understanding of ribosomes including students on graduate courses and academic researchers in biochemistry, cell biology and molecular biology as well as courses on macromolecular structure and function, advanced medical school students and both academic and pharmaceutical research scientists interested in the development of novel antibiotic drugs to target disease-resistant bacteria.


    SERIES EDITOR(S)

Prof. Thomas Steitz - Investigator, Howard Hughes Medical Institute, Sterling Professor of Molecular Biophysics and Biochemistry, Yale University, USA

Thomas A. Steitz is Sterling Professor of Molecular Biophysics and Biochemistry and an Investigator of the Howard Hughes Medical Institute at Yale University. He received his PhD at Harvard University and pursued postdoctoral research at the MRC Laboratory of Molecular Biology in Cambridge, England after which he joined the Yale faculty in 1970. He has pursued obtaining the structural basis for the mechanisms of all of the proteins and nucleic acids involved in replication of DNA, its transcription into RNA and translation into proteins. A major current interest has been structural studies of the ribosome. In 2009, along with Venki Ramakrishnan and Ada Yonath, he was awarded the Nobel Prize in Chemistry "for studies of the structure and function of the ribosome".


Series Online Publication: May 2008



     Introduction to the ribosome

The principle of translation - play sample talk extractThe principle of translation - view talk information

1. The principle of translation (21 mins)
Prof. Anders Liljas - University of Lund, Sweden

     Architecture of the ribosome RNA-protein machine assembly

High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions - play sample talk extractHigh resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions - view talk information

2. High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions (49 mins)
Prof. Nenad Ban - Swiss Federal Institute of Technology, ETH Zurich, Switzerland

The structure of the intact ribosome and ribosomal subunit interactions - play sample talk extractThe structure of the intact ribosome and ribosomal subunit interactions - view talk information

3. The structure of the intact ribosome and ribosomal subunit interactions (20 mins)
Dr. Jamie H. Doudna Cate - University of California, Berkeley, USA

Assembly of the 30S ribosomal subunit in vitro and in cells - play sample talk extractAssembly of the 30S ribosomal subunit in vitro and in cells - view talk information

4. Assembly of the 30S ribosomal subunit in vitro and in cells (38 mins)
Prof. James Williamson - The Scripps Research Institute, USA

     Decoding and peptide bond formation

How aminoacyl-tRNA synthetases translate the genetic code - play sample talk extractHow aminoacyl-tRNA synthetases translate the genetic code - view talk information

5. How aminoacyl-tRNA synthetases translate the genetic code (46 mins)
Dr. Stephen Cusack - European Molecular Biology Laboratory, Grenoble Outstation, France

Structural insights into decoding of mRNA by the ribosome - play sample talk extractStructural insights into decoding of mRNA by the ribosome - view talk information

6. Structural insights into decoding of mRNA by the ribosome (42 mins)
Prof. Venki Ramakrishnan - MRC Laboratory of Molecular Biology, UK

Chemistry of peptide bond formation - play sample talk extractChemistry of peptide bond formation - view talk information

8. Chemistry of peptide bond formation (63 mins)
Prof. Rachel Green - Johns Hopkins University, USA

Elongation of Protein Synthesis: Structural Basis of the Process of Decoding - play sample talk extractElongation of Protein Synthesis: Structural Basis of the Process of Decoding - view talk information

9. Elongation of Protein Synthesis: Structural Basis of the Process of Decoding (43 mins)
Prof. Marina Rodnina - Institute of Physical Biochemistry, University of Witten, Germany

     Initiation of protein synthesis

The structure-based mechanism of translation initiation in bacteria and eukaryotes - play sample talk extractThe structure-based mechanism of translation initiation in bacteria and eukaryotes - view talk information

10. The structure-based mechanism of translation initiation in bacteria and eukaryotes (49 mins)
Prof. Jeffrey Kieft - University of Colorado Denver School of Medicine, USA

Factor independent initiation of protein synthesis by IRES RNAs - play sample talk extractFactor independent initiation of protein synthesis by IRES RNAs - view talk information

11. Factor independent initiation of protein synthesis by IRES RNAs (48 mins)
Prof. Jeffrey Kieft - University of Colorado Denver School of Medicine, USA

     Elongation and termination of protein synthesis

Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G - play sample talk extractStructural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G - view talk information

12. Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G (27 mins)
Prof. Joachim Frank - University at Albany and Howard Hughes Medical Institute, Wadsworth Center, USA

Translocation: movement of tRNA and mRNA through the ribosome - play sample talk extractTranslocation: movement of tRNA and mRNA through the ribosome - view talk information

13. Translocation: movement of tRNA and mRNA through the ribosome (41 mins)
Prof. Harry Noller - University of California, Santa Cruz, USA

Recoding: getting more out of the message by shifting reading frame and redefining codon meaning - play sample talk extractRecoding: getting more out of the message by shifting reading frame and redefining codon meaning - view talk information

14. Recoding: getting more out of the message by shifting reading frame and redefining codon meaning (31 mins)
Prof. John Atkins - University of Utah, USA
Prof. Raymond Gesteland - University of Utah, USA

     Co-translational protein secretion

Mechanism of translocon function: current insights and models - play sample talk extractMechanism of translocon function: current insights and models - view talk information

15. Mechanism of translocon function: current insights and models (75 mins)
Prof. Arnold Driessen - University of Groningen, The Netherlands

     How antibiotics target the ribosome

Antibiotic inhibition of ribosome function - play sample talk extractAntibiotic inhibition of ribosome function - view talk information

18. Antibiotic inhibition of ribosome function (35 mins)
Dr. Daniel Wilson - Ludwig-Maximilians-Universitat Munchen,Germany

Structure-based drug design targeting infectious disease - play sample talk extractStructure-based drug design targeting infectious disease - view talk information

19. Structure-based drug design targeting infectious disease (45 mins)
Dr. Erin Duffy - Rib-X Pharmaceuticals Inc, New Haven, USA