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The InsP3 Receptor Calcium Release Channel
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    SPEAKER(S)

Prof. J. Kevin Foskett - University of Pennsylvania, USA

J. Kevin Foskett completed a PhD at the University of California at Berkeley and postdoctoral training at the National Institutes of Health. He held faculty appointments at the Naval Medical Research Center in Bethesda and the Hospital for Sick Children in Toronto before joining the faculty of the University of Pennsylvania, where he is Professor of Physiology and Developmental & Cell Biology and a member of the Institute of Neurosciences. His research for over 25 years has had as its focus the mechanisms and regulation of ion transport. This work has included active investigations of the mechanisms of intracellular Ca2+ signaling, especially the molecular physiology of the InsP3R Ca2+ release channel.

Talk Online Publication: Oct 2007

TOPICS COVERED IN THE INSP3 RECEPTOR CALCIUM RELEASE CHANNEL

The inositol trisphosphate receptor signaling system - Dynamic properties of cytoplasmic Ca2+ signals - Structural properties of the InsP3R - Patch clamp electrophysiology of the InsP3R channel - Permeation properties of the channel - Channel gating regulation by Calcium and InsP3 - Channel mechanisms that account for graded Ca2+ release - Isoform specific differences in channel gating - Channel regulation by ATP and interacting proteins

How to cite this talk:
Foskett, J.K. (2007), "The InsP3 Receptor Calcium Release Channel", in Simpson, A. (ed.), Calcium Signaling: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST29.1323_1_3&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Modulation of intracellular free Ca concentration
3. IP3 mediated calcium signals
4. Cytoplasm as an excitable medium
5. InsP3-mediated Ca release
6. IP3 receptors family
7. The InsP3R channel is a tetramer
8. Low resolution structures of the IP3 receptor
9. Atomic resolution structures for the IP3 receptor
10. Crystal structure modeling
11. Nuclear patch clamping
12. Single xenopus InsP3R channel
13. Current-voltage relation for InsP3R
14. InsP3R channel activity is regulated by [Ca]i
15. Biphasic manner of Ca regulation of InsP3R
16. Ca dependence of InsP3R: mean open duration
17. Ca dependence of InsP3R: mean closed duration
18. InsP3R channel activity is regulated by InsP3
19. How InsP3 gates the InsP3R channel
20. Na * Po
21. The number of channels activated in a patch (Na)
22. Channel recruitment enables dynamic response
23. The InsP3R channel conductance
24. Inevitable abrupt channel activity termination
25. Ligand concentration-dependence
26. Review
27. Similar channel behaviors in different species
28. Expression of rat type 3 InsP3R in Xenopus
29. Ca activation of types 1 and 3 InsP3R
30. Schematic diagram of Ca signaling elements
31. InsP3R-mediated Ca signaling
32. 3-D surface plot
33. 3-D surface plot of type 1 and 3 InsP3R
34. 3-D surface plot: cell at rest
35. 3-D surface plot: cell stimulated (type 1 channel)
36. 3-D surface plot: cell stimulated (type 3 channel)
37. Calcium induced calcium release
38. Both types 1 and 3 InsP3R propagate Ca release
39. Additional regulatory domains of the channel
40. Effect of free ATP on InsP3R Ca responses
41. The channel sensitivity to ATP changes
42. Is InsP3R localized within multi-protein complexes
43. CaBP1
44. Domain structures of CaBPs and calmodulin
45. Ca dependence of interaction of CaBP and InsP3R
46. The consequences of CaBP binding to the IP3R
47. CaBP1 binding activates InsP3R channel gating
48. Bcl-XL interacts with the IP3 receptor
49. InsP3R channel gating and Bcl-XL
50. Acknowledgements
51. END