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Genetic Susceptibility in Granulomatous Disorders: Chronic Beryllium Disease and Sarcoidosis
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    SPEAKER(S)

Prof. Lee Newman - University of Colorado at Denver and Health Sciences Center

Lee S. Newman, MD, MA, is Professor of Epidemiology in the Department of Preventive Medicine and Biometrics and Professor of Medicine in the Division of Allergy and Clinical Immunology and Division of Pulmonary Sciences and Critical Care Medicine at the University of Colorado at Denver and Health Sciences Center. His research focuses on the adaptive and innate immune basis of granulomatous disorders, metal immunotoxicology and the relationship between genetics and environmental triggers for granulomatous disease, especially chronic beryllium disease and sarcoidosis. Dr. Newman completed his BA at Amherst College and a MA in social psychology at Cornell University Graduate School of Arts and Sciences. He earned his Medical Doctorate from Vanderbilt University School of Medicine and completed his internship and residency in Internal Medicine at Emory University School of Medicine. He completed his fellowship training in pulmonary medicine in 1986 at the University of Colorado Health Sciences Center and at the National Jewish Medical and Research Center.

Talk Online Publication: Oct 2007

TOPICS COVERED IN GENETIC SUSCEPTIBILITY IN GRANULOMATOUS DISORDERS: CHRONIC BERYLLIUM DISEASE AND SARCOIDOSIS

Role of genetics x exposure in environmental lung disease - Granulomatous disorders and immunologic mechanistic basis: berylliosis and sarcoidosis - Immunogenetics that may apply generally to granulomatous disorders - Berylliosis: genetic epidemiology studies, functional genomics and gene x environment interaction studies - Role of exposure vs. genetic basis - Sarcoidosis: genetic epidemiology studies, attempts at functional genomics and directions for research to use clinical phenotype and genotype information to improve and help direct the search for an unknown causative agent - Possible implications for other (non-granulomatous) environmental lung disorders

How to cite this talk:
Newman, L. (2007), "Genetic Susceptibility in Granulomatous Disorders: Chronic Beryllium Disease and Sarcoidosis", in Christiani, D. and Fraser, P. (eds), Gene-Environment Interactions: Role in the Modulation of Pulmonary and Autoimmune Disease Risks, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST11.1139_1_3&c=252

    DETAILED SLIDE INDEX

1. Introducion
2. Outline
3. Genetics and exposure
4. Workplace immunologic disorders
5. Granulomatous disorders
6. Non-caseating granulomas
7. Non-caseating granuloma
8. Immunopathogenesis (1)
9. Immunopathogenesis (2)
10. The 'Trimolecular Complex'
11. Genetic implications
12. Granulomatous disorders: Ch 6
13. Granulomatous disorders
14. A tale of two disorders
15. Chronic Beryllium Disease (CBD)
16. CBD
17. Immunopathogenesis of CBD
18. Expression of HLA-DPB1 polymorphisms
19. Frequency of HLA -DPB1 Glu 69
20. Genetic epidemiology of CBD
21. Other genetic risk factors
22. Functional significance of genes in CBD
23. Anti-DP blocks proliferation of Be-specific T cells
24. Inhibition of Be-Induced IFN-gamma expression
25. Proliferation of CBD T-cell line to BeSO4 (1)
26. Proliferation of CBD T-cell line to BeSO4 (2)
27. Polymorphic amino acid residues of HLA-DPB1
28. Modeling of HLA-DP based on HLA-DR structure
29. TNF-alpha levels are associated with TNF genotype
30. Adaptive and innate immunity
31. Gene x environment in CBD
32. Beryllium machinist risk for CBD
33. Beryllium: exposure x Glu69
34. Non-caseating granuloma
35. Differential diagnosis (1)
36. Differential diagnosis (2)
37. Sarcoidosis
38. Epidemiology
39. Diagnostic criteria
40. Organ involvement
41. Clinical presentations
42. The challenge of sarcoidosis
43. Approach: divide and conquer
44. Genetic 'suspects' in sarcoidosis
45. Clinical subsets clarify genetic susceptibility
46. Clues from familial study
47. Combined effect of HLA-DR3, CCR2
48. TNF-alpha-307A polymorphism carrier frequencies
49. Lofgren's syndrome: population attributable risk
50. Genetics in discovering cause of sarcoidosis
51. T-cell antigen receptor usage in Lofgren
52. Strategy to find cause of Lofgren
53. Immunologic proof
54. Conclusions
55. References: beryllium (1)
56. References: beryllium (2)
57. References: beryllium (3)
58. References: beryllium (4)
59. References: beryllium (5)
60. References: sarcoidosis (1)
61. References: sarcoidosis (2)
62. References: sarcoidosis (3)
63. References: sarcoidosis (4)
64. References: other
65. End