Browse list of available series in The Biomedical & Life Sciences Collection
Recommend The Biomedical & Life Sciences Collection to your librarian
Request to be kept updated on The Biomedical & Life Sciences Collection
Apply for a free trial of The Biomedical & Life Sciences Collection
View all talks & series with full access

Guest (sample access)

Optional Login with Username


        
> Home  /  Biomedical & Life Sciences  /  Series  /  From DNA to Proteins  /  Talk Details
SHARE:   Email via Outlook   Email via Web   Facebook   Twitter   |   more
Close SHARE
Please select one of the methods below to share the following page with your collegues:
Translation Initiation
Blogger Google Reader
Delicious Linked In
Digg MySpace
Favorites PDF Online
Gmail

Hello. As a guest, you do not have full access to this talk. Click the PLAY button below to watch the sample extract. Alternatively, you may login or review methods of obtaining more access.

Printable Slide
Handouts PDF
Translation Initiation - play sample talk extract

    SPEAKER(S)

Prof. Patrick Linder - University of Geneva, Switzerland

Prof. Patrick Linder, University of Geneva, Switzerland Patrick Linder was born in 1954 and received his PhD at the University of Geneva on the control of plasmid replication in Escherichia coli. After postdoctoral work in Gif sur Yvette on nucleo-mitochondrial interaction in the budding yeast Saccharomyces cerevisiae, Dr. Linder was project leader at the Biozentrum of the University in Basel. It was during this time that he started to work on RNA helicases and translation initiation. Since then, Dr. Linder has been attached to this fascinating and central problem of the cellular life.

Talk Online Publication: Oct 2007

TOPICS COVERED IN TRANSLATION INITIATION

Main steps in translation initiation - Control of translation - Initiation factor modification - Competitive interactions for translational control - General versus gene-specific control

How to cite this talk:
Linder, P. (2007), "Translation Initiation", in Tsonis, P. (ed.), From DNA to Proteins: The Multiple Levels of Regulation , The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST6.1200&c=252

    DETAILED SLIDE INDEX

1. Introducrion
2. Overview
3. Concepts
4. The central dogma
5. Translation
6. Three steps of translation
7. Regulation of translation
8. Mechanism of translation initiation
9. Important steps in the initiation process
10. Translation initiation is complex
11. The cap
12. Cap-binding complex (eIF4F)
13. The ternary complex
14. The 40s subunit with the ternary complex
15. Regulation of translation initiation
16. General translational control
17. General translational control - Entry of ribosome
18. The regulation of the entry site
19. Molecular mimicry
20. Regulation of the 4E-BPs
21. Regulation at the level of eIF2-alfa
22. Recycling of GDP
23. The requirement for an active ternary complex
24. Phosphorylation of Eif2-alfa
25. Three steps of translation initiation
26. From general to gene specific translation control
27. Gene specific translational regulation
28. Secondary structures and upstream AUGs
29. Requirement for Gcn4 under stress
30. GCN4 mRNA (1)
31. Starvation stress allows translation of GCN4
32. GCN4 mRNA (2)
33. Starvation for amino acids
34. Inhibiting ribosome binding by cap binding proteins
35. Fe homeostasis
36. Inhibitory binding of proteins near the cap
37. Internal initiation (1)
38. Internal initiation (2)
39. mRNA specific eIF4E sequestration
40. Translation inhibition by microRNAs
41. Conclusions
42. Excellent reviews on translational control
43. END