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The principle of translation
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    SPEAKER(S)

Prof. Joachim Frank - University at Albany and Howard Hughes Medical Institute, Wadsworth Center, USA

Joachim Frank received his BS and Masters in physics at the University of Freiburg and University of Munich, respectively. He obtained his PhD from the Technical University of Munich. He received an appointment at the Wadsworth Center as a Senior Research Scientist and joined the Department of Biomedical Sciences at the University at Albany. Dr. Frank is an investigator of the Howard Hughes Medical Institute and a fellow of the AAAS and the Biophysical Society. In 2005 he gave the National Lecture at the Biophysical Society Meeting. Dr. Frank is known for his development of single-particle reconstruction methods to investigate the structure and dynamics of macromolecular assemblies and for applications of these methods in the study of ribosomal function, which has advanced the understanding of translation. In 2006, Dr. Frank was elected to the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Academy for Microbiology.

Talk Online Publication: Oct 2007

TOPICS COVERED IN THE PRINCIPLE OF TRANSLATION

Composition of the ribosome - Principle of translation - The four phases of translation - Structure and function of small and large ribosomal subunits - Role of elongation factors - The paths of messenger RNA, transfer RNA and the nascent polypeptide - Elongation cycle and binding positions of elongation factors - Decoding, peptidyl transfer and translocation - Phylogenetic conservation of ribosomal architecture

How to cite this talk:
Frank, J. (2007), "The principle of translation", in Tsonis, P. (ed.), From DNA to Proteins: The Multiple Levels of Regulation , The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST6.1146&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Composition of the eubacterial ribosome
3. Principle of translation
4. Elongation of the polypeptide chain
5. Role of elongation factors EF-G and EF-Tu
6. The four phases of translation
7. Initiation - sequence of events
8. Visualization of ribozome and translation process
9. Cryo-electron microscopy of single molecules
10. Transfer RNA - tRNA
11. Lock and key fit
12. The 70S ribosome
13. mRNA , tRNA and polypeptide interactions
14. The path of tRNA
15. The path of mRNA
16. Elongation factors and molecular mimicry
17. Implications of structural mimicry
18. Elongation cycle
19. Elongation cycle of protein biosynthesis
20. Highly conserved features in ribosomes
21. Tree diagram - philogeny of ribosomal RNA
22. END