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Factor IX
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    SPEAKER(S)

Prof. Bruce Furie - Harvard Medical School, USA

Bruce Furie is a Professor of Medicine at Harvard Medical School and Co-Chief of the Division of Hemostasis and Thrombosis. Dr. Furie's research interests focus within the area of hemostasis and thrombosis. He serves as the President of the 2009 Congress of the International Society for Thrombosis and Haemostasis and is currently on the editorial boards of Blood and Molecular Medicine.

Talk Online Publication: Oct 2007

TOPICS COVERED IN FACTOR IX

Factor IX - Blood coagulation - Thrombus formation - Factor IX gene - Vitamin Kdependent proteins and gamma-carboxyglutamic acid - Factor IX: biochemistry and structure - Hemophilia B

How to cite this talk:
Furie, B. (2007), "Factor IX", in Dunn, B. (ed.), Protein Epidemiology: Understanding Human Diseases at the Level of Protein Structure and Function, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST10.1171_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. In vivo blood coagulation
3. Thrombus formation
4. Some components of the thrombus
5. Activation of blood coagulation
6. Blood coagulation proteins
7. Structural proteins: fibrinogen
8. Factor IX gene location
9. Factor IX gene structure
10. Multiple plasma proteins
11. Glutamic acid and gamma-carboxyglutamic acid
12. Gamma carboxyglutamic acid side chain
13. Factor IX synthesized in the liver
14. Propeptides
15. Domain of vitamin K dependent proteins
16. Vitamin K dependent carboxylase
17. Factor IX: summary
18. Is carboxylasion a post/co-translational event?
19. Factor IX is a zymogen with no catalytic activity
20. Gla domain (1)
21. Gla domain (2)
22. Stability of the domain
23. Space filling model of Gla domain
24. Homology of Factor IX with thrombin
25. The hydrophobic patch
26. Factor IX in the absence of calcium
27. Formation of the complex Factor IX and XIIIa
28. Hemophilia
29. Intracranial bleed CT scan
30. Partial thromboplastin time
31. Genetic causes of hemophilia B
32. Deletions in hemophilia B
33. Changes in a single nucleotide base
34. Hemophilia B: propeptide point mutations
35. Macromolecular assembly interfering mutations
36. Zymogen activation interfering point mutations
37. Hemophilia B: enzyme activity/substrate binding
38. Factor IX
39. END