Browse list of available series in The Biomedical & Life Sciences Collection
Recommend The Biomedical & Life Sciences Collection to your librarian
Request to be kept updated on The Biomedical & Life Sciences Collection
Apply for a free trial of The Biomedical & Life Sciences Collection
View all talks & series with full access

Guest (sample access)

Optional Login with Username


        
> Home  /  Biomedical & Life Sciences  /  Series  /  Protein Epidemiology  /  Talk Details
SHARE:   Email via Outlook   Email via Web   Facebook   Twitter   |   more
Close SHARE
Please select one of the methods below to share the following page with your collegues:
Tissue Factor and Factor VII: Initiation of Blood Coagulation
Blogger Google Reader
Delicious Linked In
Digg MySpace
Favorites PDF Online
Gmail

Hello. As a guest, you do not have full access to this talk. Click the PLAY button below to watch the sample extract. Alternatively, you may login or review methods of obtaining more access.

    SPEAKER(S)

Dr. John McVey - MRC Clinical Sciences Centre, Imperial College London, UK

John McVey is a Reader and Group Leader of the Haemostasis and Thrombosis Group at Imperial College London. He is nationally and internationally recognized within the field of haemostasis, utilizing molecular genetic approaches to furthering our understanding of haemostasis. He has authored or co-authored over 70 peerreviewed papers and many reviews and book chapters in the area of blood coagulation and haemostasis.

Talk Online Publication: Oct 2007

TOPICS COVERED IN TISSUE FACTOR AND FACTOR VII: INITIATION OF BLOOD COAGULATION

Tissue factor and factor VII - Initiation of blood coagulation - Vertebrate blood coagulation - The resting state - The procoagulant response - The anticoagulant response - Molecular pathology - Tissue factor - Factor VII - Tissue factor pathway inhibitor

How to cite this talk:
McVey, J. (2007), "Tissue Factor and Factor VII: Initiation of Blood Coagulation", in Dunn, B. (ed.), Protein Epidemiology: Understanding Human Diseases at the Level of Protein Structure and Function, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST10.1344&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Learning objectives
3. Blood coagulation - primitive defence mechanism
4. Vertebrate blood coagulation
5. Blood coagulation is conserved in evolution
6. Recurrent themes in blood coagulation
7. The "resting" state
8. The procoagulant response - initiation
9. The coagulation response - propagation
10. Key points - coagulation initiation and propagation
11. Regulation of coagulation network
12. Key points - anticoagulant response
13. Coagulation regulation and molecular pathology
14. Key points - bleeding and thrombotic disorders
15. Tissue factor (TF)
16. Sites of TF expression - "haemostatic envelope"
17. Molecular pathology associated with TF
18. Agents known to induce TF expression (in vitro)
19. TF is rapidly induced
20. Factor VII
21. FVII deficiency
22. Frequency of mutations
23. Distribution of the mutations along the gene
24. FVII deficiency - example
25. Direct DNA sequence analysis (1)
26. Direct DNA sequence analysis (2)
27. Molecular modelling of FVII G117R mutation
28. Species comparison of mutated sequence
29. Prenatal diagnosis
30. TFPI
31. Key points - TFPI
32. Summary
33. END