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Phospholipase C Gamma
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    SPEAKER(S)

Prof. Graham Carpenter - Vanderbilt University School of Medicine, USA

Graham Carpenter, PhD, is a faculty member in the Department of Biochemistry at Vanderbilt University School of Medicine. He received his PhD degree from the University of Tennessee and completed his postdoctoral training at Vanderbilt University. Dr. Carpenter's interests are the signaling and trafficking mechanisms encompassing the ErbB family of growth factor receptor tyrosine kinases.

Ms. Cornelia Crooke - Vanderbilt University School of Medicine, USA

Cornelia Crooke received her BS degree at the College of Charleston and is currently a graduate student in the Department of Biochemistry at Vanderbilt University. Her research interests are focused on the role(s) of phospholipase C-gamma1 in mediating growth factor and integrin signaling events.

Talk Online Publication: Oct 2007

TOPICS COVERED IN PHOSPHOLIPASE C GAMMA

PLC-gamma in growth factor signaling - PLC-gamma as an enzyme - Substrate and products - PLC family members - Domains - Association of PLC-gamma with activated receptor tyrosine kinases and membranes - Tyrosine phosphorylation sites of PLC-gamma - PLC-gamma1 verses PLC-gamma2 - Measurement of protein and enzymatic activation - Downstream signaling by PLC-gamma in T cells - PLC-gamma mediation of integrins during adhesion and spreading - PLC-gamma biologic roles

How to cite this talk:
Carpenter, G. and Crooke, C. (2007), "Phospholipase C Gamma ", in Heldin, C. (ed.), Signal Transduction via Protein Tyrosine Kinase Receptors: Structures, Function, Regulation, Mechanisms and Role in Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST30.1113_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Receptor tyrosine kinases
3. Signal transduction pathways
4. PLC-gamma
5. PLC-gamma is an PIP2-specific hydrolytic enzyme
6. What is PIP2?
7. What is DAG?
8. Diacylglycerol production
9. What is IP3 ?
10. How is PLC-gamma activated?
11. The PI-specific PLC family
12. What defines a phospholipase C?
13. Domains in PLC-gamma 1
14. Association of PLC-gamma 1 with the receptor
15. PLC-gamma 1 association with the membrane
16. Tyrosine phosphorylation of PLC-gamma 1
17. PLC-gamma 1 Verses PLC-gamma 2
18. Measurement of PLC-gamma 1
19. Measurement of PLC-gamma tyrosine phosphorylation
20. In vivo measurement of IP3
21. In vivo measurement of intracellular Ca2+ release
22. Measurement of PLC-gamma 1 activity in vitro
23. T-Cell proliferation
24. Role of immediate early genes in cell proliferation
25. Downstream effects of PLC signaling
26. Role of PLC-gamma in IL-2 expression
27. T-cell receptor activation
28. TK phosphorylation of PLC-gamma 1 in T-cells
29. Calcium regulation of IL-2 transcription
30. DAG control of IL-2 transcription (1)
31. DAG control of IL-2 transcription (2)
32. Role of PLC-gamma in IL-2 expression
33. Cell morphogenesis
34. Role of integrins in cell morphogenesis
35. Role of PLC-gamma 1 in cell morphogenesis
36. PLC-gamma biologic roles
37. END