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The Molecular Basis of Insulin Action
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    SPEAKER(S)

Prof. Morris White - Children's Hospital, Boston and Howard Hughes Medical Institute, USA

Dr. White is an Investigator with the Howard Hughes Medical Institute. He also holds the position of Professor of Pediatrics at Harvard Medical School and Associate Scientific Staff at Children's Hospital Boston. He received his Ph.D. degree from the University of Michigan, working with Halvor Christensen on amino acid transport. After his days at the University of Michigan, he moved to the Joslin Diabetes Center, where he began his studies on the molecular aspects of insulin signaling with C. Ronald Kahn and later established his own laboratory. In 2004, Dr. White moved his laboratory to the Endocrinology Division of the Department of Medicine at Children's Hospital Boston. Dr. White was a Pew scholar in the biomedical sciences and received the Boehringer Mannheim/Juvenile Diabetes Foundation International Diabetes Care Research Award and the Outstanding Scientific Achievement Award from the American Diabetes Association. Morris White investigates the molecular basis of insulin signal transduction to understand the pathophysiology of diabetes and other disorders, including obesity, infertility, and cardiovascular and retinal disease. His studies of the insulin-signaling network reveal common elements that promote peripheral insulin action, pancreatic beta-cell growth and function, and hypothalamic control of nutrient homeostasis and fertility. His work may reveal new strategies to treat dysregulated nutrient metabolism and diabetes.

Talk Online Publication: Oct 2007

TOPICS COVERED IN THE MOLECULAR BASIS OF INSULIN ACTION

Mechanisms to diabetes - The insulin response - Growth factor receptor tyrosine kinases - The insulin receptor - The substrate hypothesis of insulin action - The family of Irs-proteins - The insulin signaling cascade - Role of the Irs2 signaling system

How to cite this talk:
White, M. (2007), "The Molecular Basis of Insulin Action", in Heldin, C. (ed.), Signal Transduction via Protein Tyrosine Kinase Receptors: Structures, Function, Regulation, Mechanisms and Role in Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST30.1158_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Mechanisms to diabetes
3. The insulin response
4. Growth factor receptor tyrosine kinases
5. Insulin and its receptor
6. Insulin receptor
7. Insulin receptor transmembrane signaling
8. Insulin and IGF1 receptors exist as hybrids
9. Growth factor receptor tyrosine kinases
10. The substrate hypothesis of insulin action
11. The family of Irs-proteins
12. Insulin signaling cascade
13. Insulin stimulates GLU4 translocation
14. The insulin signaling cascade
15. The insulin signaling cascade inhibition
16. IRS-proteins mediated insulin action
17. IRS2 integrates central & peripheral homeostasis
18. IRS2 regulates hepatic glucose homeostasis
19. IRS2 signaling promotes glucose homeostasis
20. IRS signaling regulates the expression of Pdx-1
21. Integrated view of IRS signaling system
22. END