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Sodium-Calcium Exchange
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    SPEAKER(S)

Prof. John Reeves - University of Medicine and Dentistry of New Jersey, USA

John Reeves received his PhD in biology from MIT in 1969 and did postdoctoral training in the laboratories of Drs. Wayne Umbreit and Ronald Kaback. He has held positions at Allen University, Columbia SC (1969-79), University of Texas Southwestern Medical School (1973-82), the Roche Institute of Molecular Biology (1982-93) and New Jersey Medical School (1993-present). He has a long-standing interest in carrier mediated transport, with special emphasis on Na/Ca exchange. His research is supported by the National Institutes of Health and the American Heart Association.

Talk Online Publication: Oct 2007

TOPICS COVERED IN SODIUM-CALCIUM EXCHANGE

The definition and thermodynamic driving forces for Na/Ca exchange and the historical development of the field - The molecular biology of Na/Ca exchange family members - The regulation of Na/Ca exchange - The physiological functions of Na/Ca exchange in cardiac physiology, hypertension and higher neural functions

How to cite this talk:
Reeves, J. (2007), "Sodium-Calcium Exchange", in Simpson, A. (ed.), Calcium Signaling: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST29.1414_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Na/Ca exchange (NCX) - overview
3. NCX and Ca homeostasis
4. Energetics of Na/Ca exchange
5. NCX is bi-directional
6. K-dependent Na/Ca exchange: NCKX
7. A brief history of Na/Ca exchange
8. NCX exchanger families
9. NCX1 protein
10. Splice variants of NCX1
11. Helix packing of NCX1
12. Consecutive reaction mechanism
13. Overview of NCX regulation
14. PIP2 blocks Na-dependent inactivation
15. PIP2 interacts with XIP
16. Regulatory Ca binding sites
17. Persistent Ca activation
18. Anomalous Ca regulation in drosophila
19. Squid axon Na/Ca exchanger
20. NCX and cardiac myocyte physiology
21. Cytosolic Na and cardiac contractility
22. NCX expression studies
23. NCX and cardiac pathophysiology
24. NCX inhibitors
25. NCX and hypertension?
26. Higher order NCX functions
27. END