Browse list of available series in The Biomedical & Life Sciences Collection
Recommend The Biomedical & Life Sciences Collection to your librarian
Request to be kept updated on The Biomedical & Life Sciences Collection
Apply for a free trial of The Biomedical & Life Sciences Collection
View all talks & series with full access

Guest (sample access)

Optional Login with Username


        
> Home  /  Biomedical & Life Sciences  /  Series  /  Calcium Signaling  /  Talk Details
SHARE:   Email via Outlook   Email via Web   Facebook   Twitter   |   more
Close SHARE
Please select one of the methods below to share the following page with your collegues:
Ryanodine Receptors and Cardiac Function
Blogger Google Reader
Delicious Linked In
Digg MySpace
Favorites PDF Online
Gmail

Hello. As a guest, you do not have full access to this talk. Click the PLAY button below to watch the sample extract. Alternatively, you may login or review methods of obtaining more access.

    SPEAKER(S)

Prof. David Eisner - University of Manchester, UK

David Eisner completed a DPhil with Denis Noble in Oxford before working at University College London and the University of Liverpool. He is currently the British Heart Foundation Professor of Cardiac Physiology in Manchester. His research interests focus on mechanisms responsible for the control of calcium in the heart and the interactions with contraction and arrhythmias.

Talk Online Publication: Oct 2007

TOPICS COVERED IN RYANODINE RECEPTORS AND CARDIAC FUNCTION

Introduction to Calcium cycling in the heart - How to measure SR and sarcolemmal Calcium fluxes - What controls SR Calcium content - The effects of changing the open probability of the RyR - The link between Calcium and arrhythmias - Mechanisms responsible for alternans in the heart

How to cite this talk:
Eisner, D. (2007), "Ryanodine Receptors and Cardiac Function", in Simpson, A. (ed.), Calcium Signaling: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST29.1461_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. The systolic Ca transient
3. RyR and Ca induced Ca release from the SR
4. What controls the size of the Ca transient?
5. What produces stability of SR and systolic Ca?
6. Quantifying SR Ca content in cardiac myocytes
7. Sarcolemmal Ca entry = exit
8. How is SR content controlled?
9. Measuring cytoplasmic calcium concentration
10. SR Ca content controls sarcolemmal fluxes
11. Control of Ca entry and efflux by Ca transient
12. Does RyR modulatrion alter cardiac contractility?
13. Effects of RyR potentiating with caffeine
14. Ca and arrhythmias
15. Can't increase SR Ca beyond a certain threshold
16. Ca waves are arrhythmogenic
17. Mutations in the RyR - arrhythmias
18. Selective removing of arrhythmias
19. Depressing RyR opening with tetracaine
20. Pulsus alternans
21. Alternans due to excessive feedback control
22. Excessive feedback gain
23. Two experimental models of alternans
24. Does SR content alternate?
25. Alternans accompanied by SR content alternans
26. Confocal linescans in control
27. Steep dependence of Ca release on SR content
28. Similar waves seen with acidosis or tetracaine
29. Ca waves during alternans
30. Working model: changes of SR Ca - alternans
31. Working model summary cartoon (1)
32. Working model summary cartoon (2)
33. Summary
34. Acknowledgements
35. END