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Voltage-Dependent Calcium Channels
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    SPEAKER(S)

Prof. Annette Dolphin - University College London, UK

Annette C. Dolphin received her BA in natural sciences (biochemistry) from the University of Oxford and her PhD at the Institute of Psychiatry in London. She held postdoctoral fellowships at the College de France in Paris and at Yale University before returning to a post at the National Institute for Medical Research. She then took up a lectureship at St. George's Hospital Medical School, London, and was appointed to the Chair of Pharmacology at the Royal Free Hospital School of Medicine in 1990. Her work is on voltage-gated calcium channels and she is particularly interested in neuronal calcium channel function.

Talk Online Publication: Oct 2007

TOPICS COVERED IN VOLTAGE-DEPENDENT CALCIUM CHANNELS

Introduction to voltage-gated calcium channels - Correlation of known structural features to function - Subtypes of calcium channels and their physiological correlates - Pharmacology of voltage-gated calcium channels - G protein modulation of certain subtypes of voltage-gated calcium channels - Calcium channelopathies

How to cite this talk:
Dolphin, A. (2007), "Voltage-Dependent Calcium Channels", in Simpson, A. (ed.), Calcium Signaling: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST29.1474_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Properties of voltage-activated calcium channels
3. Voltage clamp of Ca currents
4. Why is the IV plot for calcium currents U shaped?
5. Tail currents (1)
6. Tail currents (2)
7. Physiological sequence during tansmitter release
8. alpha-1 subunit of the channel
9. Voltage sensor
10. Domain I of alpha1B subunit (rabbit)
11. Ca selectivity
12. Role of glutamate residue in Ca selectivity (1)
13. Role of glutamate residue in Ca selectivity (2)
14. Permeation
15. Calcium channel classes
16. Calcium channel pharmacology (1)
17. Calcium channel pharmacology (2)
18. Structure of omega-conotoxins
19. Calcium channel pharmacology
20. Some functions of alpha-1 subunits
21. Auxiliary subunits enhance current
22. Beta subunit of the channel
23. Beta subunit is required to target alpha-1
24. Effects of beta and alpha-2-deltha on Ca currents
25. Roles of Ca channel alpha-2-deltha subunits (1)
26. Roles of Ca channel alpha-2-deltha subunits (2)
27. Alpha2deltha effect on voltage-gated Ca currents
28. Alpha2deltha effect on voltage-gated Ca currents
29. Roles of calcium channel gamma subunits
30. Calcium channel classes
31. GABA agonist baclofen
32. Inhibitory modulation of calcium channels
33. Ca channels are subject to G protein modulation
34. G protein regulation of Ca channels (1)
35. G protein regulation of Ca channels (2)
36. Evidence modulation by G-beta-gamma
37. Channelopathies associated with alpha-1 subunits
38. Hypokalaemic periodic paralysis
39. Episodic ataxia-2 mutations
40. Spinocerebellar ataxia-6
41. Familial hemiplegic migraine
42. Mouse mutants with SWD and cerebellar ataxia
43. Structure of voltage-dependent calcium channels
44. END