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> Home  /  Biomedical & Life Sciences  /  Series  /  Neurodegenerative Diseases  /  Talk Details
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Neurodegenerative Disease: Expression Levels of Normal Sequence Pathogenic Proteins Contribute to Risk of Disease
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    SPEAKER(S)

Prof. John Hardy - Laboratory of Neurogenetics, National Institute of Aging, NIH, USA

John Hardy is a geneticist and molecular biologist whose research interests focus on neurological disease. Dr. Hardy received his BSc (Hons) degree from the University of Leeds, UK (1976) and his PhD from Imperial College, London. Dr. Hardy received his postdoctoral training at the MRC Neuropathogenesis Unit in Newcastle upon Tyne, UK and then further postdoctoral work at the Swedish Brain Bank in Umea, Sweden where he started to work on Alzheimer’s disease. He won the MetLife, the Allied Signal and the Potamkin Prize for his work in describing the first genetic mutations, in the amyloid gene in Alzheimer’s disease, in 1991. He was Head of the Neurogenetics Section, National Institute of Aging, Bethesda, USA and in 2007 took up the Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology.

Talk Online Publication: Oct 2007

TOPICS COVERED IN NEURODEGENERATIVE DISEASE: EXPRESSION LEVELS OF NORMAL SEQUENCE PATHOGENIC PROTEINS CONTRIBUTE TO RISK OF DISEASE

Protein pathology of disease - Loci underlying autosomal dominant neurodegenerative disease - Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease - Tau mutations cause autosomal dominant frontal temporal dementia - Alpha-synuclein mutations cause autosomal dominant Parkinson's disease - How genetic variability of these genes contributes to the risk of sporadic disease

How to cite this talk:
Hardy, J. (2007), "Neurodegenerative Disease: Expression Levels of Normal Sequence Pathogenic Proteins Contribute to Risk of Disease", in Hodges, J. (ed.), Neurodegenerative Diseases: Fundamentals, Research Methods, Latest Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST20.1049&c=252

    DETAILED SLIDE INDEX

1. Intro slide
2. Pathology of diseases
3. Basic hypothesis
4. A prescient suggestion
5. Down's syndrome and Alzheimer's disease
6. Alzheimer's disease
7. Amyloid precursor protein and PS1
8. APP metabolism
9. APP mutations
10. Sporadic Alzheimer's disease
11. Linkage curve
12. Conclusions on Alzheimer's disease
13. Prion diseases
14. First family with a prion mutation
15. CJD
16. Sporadic CJD
17. Prion disease conclusions
18. Tau pathology
19. Tau protein
20. Tau mutations cause diseases
21. Alterations in exon splicing
22. Tau haplotypes
23. Tau & PSP
24. Primary tauopathies
25. Lewy bodies
26. Mutations in alpha-synuclein
27. Synuclein and sporadic Parkinson's disease
28. Iowa kindred structure
29. Alpha-synuclein pathologies
30. Chromosomal spreads (FISH)
31. Lewy bodies disease conclusions
32. Overall conclusions
33. END