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Motor Neurone Disease: Clinical Aspects
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    SPEAKER(S)

Dr. Kevin Talbot - Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, UK

Kevin Talbot is a clinical neurologist and clinician scientist at the University of Oxford. He is Director of the Oxford MND Care Centre and runs a research group investigating the basic pathogenesis of Motor Neurone degeneration using cellular and animal models. He trained in medicine and neurology in London and Oxford.

Talk Online Publication: Oct 2007

TOPICS COVERED IN MOTOR NEURONE DISEASE: CLINICAL ASPECTS

Main clinical subtypes of MND - Neuropathological features - Molecular pathology and prognosis - Multidisciplinary management - Effectiveness of current drug treatments

How to cite this talk:
Talbot, K. (2007), "Motor Neurone Disease: Clinical Aspects", in Hodges, J. (ed.), Neurodegenerative Diseases: Fundamentals, Research Methods, Latest Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST20.1044_1_2&c=252

    DETAILED SLIDE INDEX

1. Intro slide
2. Motor neurone diseases
3. MND: a neurodegenerative disease
4. Definition
5. Synonyms
6. Epidemiology
7. Age of onset
8. ALS: spinal onset
9. Relevant investigations
10. ALS: bulbar onset
11. Relevant investigations
12. Progressive Muscular Atrophy
13. Primary Lateral Sclerosis
14. Regional variants
15. Diagnosis
16. El-Escorial Criteria
17. Clinical utility of El-Escorial criteria
18. Conveying the diagnosis
19. Clinical progression
20. Natural history of MND/ALS
21. Prognostic guides
22. One disease or many?
23. Molecular neuropathology: Bunina bodies
24. Molecular neuropathology: skein-like inclusions
25. Hyaline inclusions
26. Dystrophic neurites
27. Familial ALS/MND
28. SOD1 associated ALS/MND
29. Clinical follow up
30. The Care Team
31. Drugs treatments
32. Evidence for clinical benefit with riluzole
33. Human therapeutic trials
34. Treatable symptoms
35. Enablement
36. Weight loss
37. Nutritional management
38. Assessment of respiratory function
39. Respiratory care
40. ALS as a multisystem disease
41. Cognitive impairment
42. Neuropathology of MND dementia
43. Key points
44. The future
45. END