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Pregnancy in Autoimmune Rheumatic Diseases
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    SPEAKER(S)

Prof. Angela Tincani - Spedali Civili and University of Brescia, Italy

Dr. Tincani is Associate Professor in Rheumatology, University of Brescia and Deputy Director of Rheumatology and Clinical Immunology, Brescia General Hospital, Italy. Dr. Tincani's main interests include: pathogenesis, diagnosis and treatment of systemic autoimmune diseases, problems connected to the pregnancy in patients with rheumatic diseases, evolution of autoantibodies determinations and reliability and clinical significance of emerging new technology. Dr. Tincani is the regional Editor (Europe) of the journal Autoimmunity. Dr. Laura Andreoli and Dr. Angela Ceribelli - Brescia General Hospital, Italy Dr. Laura Andreoli and Dr. Angela Ceribelli are specialist doctors in rheumatology at Brescia General Hospital. Their main interests are diagnosis and follow-up of systemic autoimmune diseases and evaluation of autoantibodies clinical significance.

Talk Online Publication: Oct 2007

TOPICS COVERED IN PREGNANCY IN AUTOIMMUNE RHEUMATIC DISEASES

Pregnancy and the immune system - SLE flares during pregnancy - Gestational outcome in SLE - Predictors of obstetrical and neonatal complications in SLE - Autoantibodies that can affect pregnancy outcome: antiphospholipid antibodies - Obstetrical complications and newborns outcome in antiphospholipid syndrome - Autoantibodies that can affect pregnancy outcome: anti-Ro/SS-A antibodies - Neonatal lupus - Congenital heart block and in utero exposure to dexamethasone

How to cite this talk:
Tincani, A. (2007), "Pregnancy in Autoimmune Rheumatic Diseases", in Shoenfeld, Y. (ed.), Autoimmunity: Etiology, pathogenesis, clinical manifestation and diagnostic methodologies, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST16.1453_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Pregnancy and the immune system
3. SLE and flares during pregnancy
4. Pregnancies and patients studied
5. Flare definition applied in pregnancy
6. Physician judgement and disease activity index
7. Flare definition
8. Timing of SLE flares in pregnancy
9. Flare frequency by timing of pregnancy
10. ECLAM score / estrogen levels during pregnancy
11. Can we know flare occurrences in advance ?
12. Significant predictors of flares
13. Pregnant women with SLE can have flares
14. Gestational outcome in SLE
15. Impact of lupus activity on obstetric outcome
16. Gestational outcome in SLE: example
17. Gestational outcome in renal SLE
18. Identifying patients with a high risk of baby loss
19. Predictors of adverse pregnancy outcome
20. Predictors of obstetrical /neonatal complications
21. Factors that predict prematurity and preeclampsia
22. Autoantibodies that affect pregnancy outcome
23. Antiphospholipid (APL) antibody definition
24. Antiphospholipid (APL) antibody associations
25. Beta-2 glycoprotein I (beta-2GPI)
26. Two-hit theory in APS
27. Placenta: the target of aPL
28. Beta-2GPI binds the trophoblast cell membranes
29. Revised classification for APS syndrome
30. Antiphospholipid antibodies and autoimmunity
31. APS is treatable cause of prgnancy loss
32. Obstetrical complications
33. Newborns from mothers with primary APS (1)
34. Newborns from mothers with primary APS (2)
35. Thrombosis in the offspring of APS patients
36. Transplacental passage of IgG aPL (1)
37. Transplacental passage of IgG aPL (2)
38. aPL in 12 month old babies
39. The influence on fetal development
40. Mental developement and maternal autoAbs (1)
41. Mental developement and maternal autoAbs (2)
42. Clinical success and open questions
43. Register of infants from mothers with APS
44. IgG isotope can influence pregnancy
45. Ro complex
46. Anti-Ro/anti-La and autoimmunity
47. Anti Ro/SS-A and gestational outcome
48. Neonatal lupus model
49. Anti Ro/SS-A and congenital heart block (CHB)
50. Proposed mechanism of cardiac damage
51. The diagnosis of CHB
52. In utero detection of first-degree heart block
53. Management of CHB
54. Antenatal and postnatal exposure to DEX
55. 11 CHB children with/without exposure to DEX
56. T-cell evaluation in eight DEX exposed children
57. Heteroduplex analysis on TCRBV chains
58. Oligoclonal expansions of TCR repertoire
59. Alessa - case study
60. Second pregnancy - case study
61. Acknowledgements and contacts
62. END