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The Y-chromosome
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    SPEAKER(S)

Prof. Mark Jobling - University of Leicester, UK

Mark Jobling is a Wellcome Trust Senior Fellow in Basic Biomedical Science. He received his undergraduate training and DPhil at the University of Oxford before moving to the Genetics Department of the University of Leicester in 1992. Mark is interested in human genetic diversity, and the molecular- and population-level processes that underlie this, with a focus on the human Y chromosome.

Talk Online Publication: Dec 2009

TOPICS COVERED IN THE Y-CHROMOSOME

Role in sex determination - Recombination behaviour - Sex-chromosomal aneuploidies - Type and number of genes - Rates and types of mutation - Associated diseases - Sequence organization - Diversity of Y chromosome types in populations

How to cite this talk:
Jobling, M. (2009), "The Y-chromosome", in Veeramah, K. (ed.), Introduction to Human Genetics: Fundamentals and latest advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST19.2429_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Chromosomes of a human male: 46,XY
3. The Y chromosome is dominantly sex-determining
4. Ovary or testis?
5. Specialized for sex
6. The human sex chromosomes
7. Evolution of the sex chromosomes
8. Pseudoautosomal region 1 (PAR1)
9. XY pairing in pachytene
10. A gradient of recombination in PAR1
11. Pseudoautosomal region 2
12. Sex-chromosomal recombination
13. Identifying the testis-determining factor
14. Translocation XX males and XY females
15. Principle of deletion mapping the TDF interval
16. Sex-determining region Y (SRY)
17. Evidence that SRY is TDF
18. Randy the transgenic mouse
19. The SRY gene and protein
20. The sex-determining pathway downstream of SRY
21. Turner syndrome
22. Turner syndrome (45,X) phenotype
23. Turner syndrome and X-linked genes
24. Turner syndrome - candidate genes
25. XY-homology
26. Y-chromosomal aneuploidies
27. A high mutation rate on the Y
28. The weird genomic landscape of the Y
29. Y-linked inheritance
30. Other Y-associated phenotypes?
31. Y-linked deafness (DFNY1)
32. The human Y carries fertility factors
33. Testis histologies in normal and infertile males
34. Finding AZF candidate genes
35. AZF phenotypes and candidate genes
36. Genomic disorders
37. NAHR in AZFa and AZFc infertility
38. The 'hall of mirrors'
39. Complex structural rearrangements
40. Substrates for gene conversion
41. Gene conversion is biased
42. 'Genetic coherence' of the Y
43. PAR1 shows no 'genetic coherence'
44. A single ancestor for the Y
45. Genome segments and effective population sizes
46. Y haplogroup distribution
47. Applications of Y diversity
48. Thanks
49. END