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Molecular pathogenesis and prevention of Staphylococcus aureus infections
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    SPEAKER(S)

Prof. Olaf Schneewind - University of Chicago, USA

Olaf Schneewind is Professor and Chair of the Department of Microbiology at the University of Chicago. He received his MD and PhD from the University of Cologne in 1988. He obtained subsequent postdoctoral training at Rockefeller University's Laboratory of Bacteriology and Immunology under the mentorship of Dr. Vincent Fischetti. In 1992, he received his first appointment as Assistant Professor in the Department of Microbiology and Immunology at the University of California, Los Angeles School of Medicine, where he was subsequently promoted to Associate Professor (1997) and Professor (2001). Dr. Schneewind then joined the Biological Sciences Division faculty at the University of Chicago in 2001. Dr. Schneewind's research program examines the mechanisms and strategies whereby pathogenic bacteria cause human diseases. His research has produced more than 75 peer-reviewed publications and several book chapters. Dr. Schneewind has also served as an editorial board member for Molecular Microbiology, Journal of Bacteriology, and Trends in Microbiology.

Talk Online Publication: Nov 2009

TOPICS COVERED IN MOLECULAR PATHOGENESIS AND PREVENTION OF STAPHYLOCOCCUS AUREUS INFECTIONS

The envelope of gram-positive bacteria - Anchoring proteins - Signal peptides of staphylococcal surface proteins - Protein traffic to the cell wall envelope of S. aureus - Fate of S. aureus injected into mice bloodstream - Abscess formation - What are the protective antigens of staphylococci? - Surface proteins and protective immunity - Staphylococcal abscesses enable persistence - Protein topologies in the cell wall of staphylococci - Vaccine protection against lethal challenge - S. aureus and human lung infections - Active/passive immunization

How to cite this talk:
Schneewind, O. (2009), "Molecular pathogenesis and prevention of Staphylococcus aureus infections", in Finlay, B. (ed.), Molecular Basis of Bacterial Infection: , The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)

Direct talk access link:
http://hstalks.com/lib.php?t=HST92.2454_1_2&c=252

    DETAILED SLIDE INDEX

1. Introduction
2. Staphylococcus aureus
3. The envelope of gram-positive bacteria
4. Protein A
5. Sortase A - anchoring proteins
6. S. aureus sortase A mutants
7. Sortase A cleavage of LPXTG peptides
8. Sortase A catalyzed transpeptidation
9. LPXTG peptide bound to sortase A
10. Deposition of protein A in the envelope
11. Protein A on the staphylococcal surface
12. Signal peptides of staphylococcal surface proteins
13. Distribution of surface proteins in cell wall envelope
14. SPs address proteins to specific locations
15. Protein traffic to the cell wall envelope of S. aureus
16. Fate of S. aureus injected into mice bloodstream
17. Abscess formation in the kidney of mice
18. Architecture of day 2 lesions
19. Architecture of day 5 lesions
20. SEM of staphylococci in host tissues
21. Sortase mutants cannot form abscesses
22. Sortase A is essential for persistence in host
23. Sortase mutants in renal tissue
24. Surface abscesses in wt and srtA mutants
25. Surface proteins involved in abscess formation
26. What are the protective antigens of staphylococci?
27. Surface proteins and protective immunity
28. Vaccine against abscess with IsdAB/SdrDE
29. Staphylococcal abscesses enable persistence
30. Heme-iron transport in staphylococci
31. Sortase B and the IsdC anchor structure
32. Protein topologies in the cell wall of staphylococci
33. Staphylococcal envelope associated proteins
34. Eap and Emp
35. Lack of envelope associated proteins
36. Eap mutants form abscesses
37. Emp mutants cannot form abscesses
38. Distribution of Eap, Emp in abscess formation
39. Eap and Emp vaccines
40. Vaccine protection against lethal challenge
41. S. aureus and human lung infections
42. Staphylococcus aureus pneumonia in mice
43. Murine pneumonia model
44. Mechanisms of Hla assembly and function
45. Hla is an essential virulence factor for S. aureus
46. Active immunization with Hla
47. Passive immunization with Hla antibodies
48. Summary and acknowledgments
49. END