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1. Introduction
2. Intravital imaging of macrophages
3. Macrophages functions
4. TAMs subvert normal macrophage functions
5. Tumor-stroma interactions
6. TAMs density and prognosis
7. CSF-1 and macrophage chemokines
8. CSF-1 promotes tumor progression to metastasis?
9. A robust staging system for PyMT tumors
10. Delayed tumor progression without macrophages
11. Pulmonary metastasis inhibition
12. CSF-1 and tumor regulation
13. CSF-1 expression in mammary gland
14. Macrophages staining in the -/- (CSF-1 Tg+) mice
15. Tumor progression at 18 weeks of age
16. TAMs density in tumor
17. Macrophages promote invasive microenvironment
18. Tumor cells migration and macrophages
19. Micro needle invasion assay
20. Needle collection and CSF-1 and EGF signalling
21. Cell specific gene expression profiles
22. Needle collection of cells requires macrophages
23. Tumor cell macrophage interaction
24. Macrophages and tumor cells
25. Paracrine loop-relayed chemotaxis
26. The six traits
27. Vessel network formation and tumor progression
28. Malignancy and the angiogenic switch
29. Stage of macrophages recruitment
30. Angiogenesis mechanism
31. Vessel network formation in WT/ CSF1 null mice
32. Macrophage depletion reduces vascularization
33. Macrophage depletion and vessel area and density
34. IHC of VEGF in PyMT tumor
35. VEGF expression vector using the 2A system
36. VEGF effect
37. VEGF over-expression
38. Introducing macrophages in an earlier stage
39. CSF-1 effect
40. CSF-1 over expression
41. CSF-1 transgenic expression
42. Tumor movement and macrophages
43. Where do the macrophages localize?
44. Tumor cell motility
45. Intravasation
46. The invasive microenvironment
47. Paracrine interactions
48. Acknowledgements

Topics Covered

• Tumor microenvironment
• Macrophages promote tumor progression and metastasis
• Macrophage densities correlate with poor prognosis in many human cancers
• Macrophages regulate tumor cell migration and intravasation
• Macrophages regulate the angiogenic switch at the malignant transition
• Macrophage and tumor cells move using a paracrine mechanism involving CSF-1 and EGF
• Macrophages synthesize VEGF to regulate angiogenesis

Links

Series:

• Innate Immunity

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Pollard, J. (2009, May 31). Macrophages, a cellular toolbox used by tumors to promote progression and metastasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1319/.
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Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Jeffrey Pollard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.