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Navigable Slide Index

1. Introduction
2. Rhodopsin: prototype GPCR
3. Major classes of GPCRs
4. Class I: rhodopsin-like
5. Class II: glucagon-like
6. Class III: mGlu-like
7. Experimental approaches to study GPCR structure
8. Rhodopsin crystal structure
9. Post-translational modifications
10. Mechanisms of ligand interaction
11. Rhodopsin
12. Neurotransmitter binding
13. Peptide hormone: receptor complexing
14. Glycoprotein hormone receptors
15. GPCR activation
16. Terniary and extended terniary model
17. Rigid body model
18. Rigid body model: ESR evidence
19. SJ receptor
20. Coupling promiscuity
21. Signal trafficking
22. Agonist-directed signaling - role in drug specificity
23. Involvement of non-G protein signaling
24. Mechanism of hallucinogens
25. Receptor RNA processing/isoforms
26. RNA editing
27. GRKs/arrestin
28. Arrestin-dependent internalizaton
29. Non-heterotrimeric G protein coupling
30. Dimerization
31. Rhodopsin dimerization
32. Functional D2R SSTR5 dimer
33. RAMPs (receptor activity modifying protein)
34. Biological functions for RAMPs
35. RAMPs, heterodimers and expression
36. GPCRs and disease
37. Thyroxine and thyrotropin during pregnancy
38. cAMP production in WT and mutants
39. Suggestions for further reading, acknowledgments

Topics Covered

• Rhodopsin: prototype GPCR
• Major classes of GPCRs: rhodopsin-like, glucagon-like, mGlu-like
• Experimental approaches to study GPCR structure
• Rhodopsin crystal structure
• GPCR activation
• Signal trafficking
• Receptor RNA processing/isoforms
• GRKs/arrestin
• Rhodopsin dimerization
• RAMPs: receptor activity modifying protein
• RAMPs, heterodimers and expression
• GPCRs and disease
• Thyroxine and thyrotropin

Links

Series:

• The World of Hormones

Categories:

• Biochemistry

Talk Citation

Sealfon, S. (2007, December 1). G-protein coupled receptors: hormone membrane receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 28, 2024, from https://doi.org/10.69645/WCAO9566.
Export Citation (RIS)

Publication History

• Published on December 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Stuart Sealfon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.