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1. Introduction
2. Scientific classification of the genus Yersinia
3. Common features
4. Classification of strains
5. Level of pathogenicity
6. Overview of Yersinia infections
7. Intestinal Yersinia infections
8. Intestinal Yersinia infections: transmission
9. Intestinal infections: outcomes (1)
10. Intestinal infections: outcomes (2)
11. Plague: overview
12. Transmission modes of Y. pestis
13. Unique features of Y. pestis (1)
14. Unique features of Y. pestis (2)
15. Plague: bubonic
16. Plague: pneumonic (1)
17. Plague: pneumonic (2)
18. Attributes of a successful bacterial pathogen
19. Adhesion and invasion determinants
20. Mechanism of Yersinia invasion
21. Invasin
22. Mechanism of invasin-promoted uptake
23. Systemic infection may bypass lymph colonization
24. Regulate gene expression
25. Avoid, subvert or co-opt host immune responses
26. Localization of Y. pseudotuberculosis in cells
27. Extracellular location of Y. enterocolitica
28. Simplified Yersinia pathogenesis model
29. Summary of vacuole trafficking studies
30. Model of "YCV" trafficking
31. Simplified Yersinia pathogenesis model
32. pCD1 encodes type III protein secretion system
33. Yersinia type III secretion system
34. Overview of Yop effectors
35. Inhibition of signaling pathways by Yops
36. The type III "injectisome"
37. LcrV
38. Acquire nutrients to replicate
39. Genes involved in uptake of iron
40. Some open questions in Yersinia pathogenesis
41. Acknowledgements
42. References

Topics Covered

• Classification of strains
• Different degrees of pathogenicity
• Intestinal Yersinia infections: transmission and outcomes
• Transmission modes of Y. pestis
• Pneumonic and bubonic plague
• Adhesion and invasion
• Invasin
• Gene expression
• Vacuole trafficking
• Secretion systems

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 29, 2009

Financial Disclosures

• Prof. James Bliska has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.