Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Core hematology parameters
3. Minimizing variability
4. Physiological / procedural variability
5. Effect of strain
6. Effect of excitement / fear
7. Effect of restraint stress on leukocytes (rats)
8. Effect of collection time on leukocyte counts
9. Effect of collection site (mice)
10. Artifact
11. Other contributors to variability
12. Appropriate use of reference intervals
13. Some good study design practices
14. Purpose of hematology tests
15. Predictability for human hematotoxicity >/= 90%
16. Classification of hematologic effects
17. RBC parameters
18. Control of erythropoiesis
19. Instruments with animal-specific applications
20. Hemoglobin concentration
21. Red cell counting and sizing (RBC, MCV)
22. Red cell counting and sizing (HCT, RDW)
23. RBC vs. MCV: inverse relationship
24. Calculated red cell indices & reticulocyte counting
25. RBC and reticulocyte analysis
26. Characteristics of young red cells
27. Correlation of RBC data
28. Increased red cell mass (HGB, HCT, RBC)
29. Decreased red cell mass (HGB, HCT, RBC)
30. Absolute decreased red cell mass
31. Red cell loss (hemorrhage)
32. Red cell destruction (hemolysis)
33. Red cell loss or destruction
34. Differences in RBC lifespan affect responses (1)
35. Extramedullary hematopoiesis
36. Decreased red cell production: causes
37. Decreased red cell production: characteristics
38. Differences in RBC lifespan affect responses (2)
39. Anemia of chronic disease (1)
40. Anemia of chronic disease (2)
41. WBC parameters
42. Counting and classifying leukocytes
43. Advia
44. Total WBC counts
45. Species differences: lymphocyte/neutrophil ratio
46. Leukocyte kinetics in health
47. Increased leukocytes
48. Decreased leukocytes
49. Platelet parameters
50. Platelets - overview
51. Platelet counting and sizing
52. Increased platelets
53. Changes in platelet size
54. Decreased platelets
55. Hematopoiesis
56. Bone marrow evaluation
57. Summary
58. Acknowledgements
59. Abbreviations

Topics Covered

• Minimizing effects of preanalytical variables on hematology tests
• Proper use of reference intervals
• Evaluating rbc parameters
• Evaluating leukocyte parameters
• Evaluating platelet parameters
• Preparation and evaluation of bone marrow smears

Links

Series:

• Non-Clinical Testing for Toxicity of Pharmaceuticals

Categories:

• Pharmaceutical Sciences

Therapeutic Areas:

• Haematology

Talk Citation

Publication History

• Published on August 26, 2009

Financial Disclosures

• Dr. Nancy Everds has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.