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1. Introduction
2. Talk outline
3. Multiple CNS pathways of pain signalling
4. Cortical regions that are involved in pain
5. Brain imaging to visualize regions activated by pain
6. Cortical network activated by pain
7. Pain is a complex experience
8. Pain activation in ACC and IC
9. Cortical regions involved in pain modulation
10. Information from cortex to the spinal cord
11. Psychological conditions can alter pain
12. Attentional state modulates pain
13. Shifting attention away from pain
14. Distraction from pain makes it weaker
15. Pain reduced during distraction
16. Attentional modulation in S1 and insular cortex
17. Commonly used distraction task
18. Heat pain activation when attention to pain
19. Cingulofrontal-PAG circuit activated during Stroops
20. Emotional state alters pain
21. Studies to separate attention and emotions
22. Mood and pain
23. Mood predicts pain unpleasantness
24. Mood alters pain-evoked activity
25. Emotional modulation and attentional modulation
26. Empathy and pain
27. Testing the effect of empathy on pain perception
28. High empathy = more pain
29. Placebo analgesia
30. Effect of a drug is a combination of parameters
31. Placebo effects in a number of disorders
32. The placebo effect can be created in two ways
33. Expectation-induced placebo analgesia
34. Imaging placebo analgesia (1)
35. Imaging placebo analgesia (2)
36. Forebrain involvement in opiate analgesia
37. Imaging of opiate analgesia
38. PET can determine receptors related to analgesia
39. Pain-related opiate binding
40. Forebrain dopamine involved in pain modulation
41. Dopamine release in response to muscle pain
42. Conclusions
43. Thank you

Topics Covered

• Involvement of the forebrain in pain perception
• Descending pain control pathways from cortex
• Attentional modulation of pain
• Emotional modulation of pain
• Empathy and pain
• Placebo analgesia
• Role of forebrain opiates and dopamine in analgesia

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009

Financial Disclosures

• Prof. M. Catherine Bushnell, Speaker's Bureau: Lilly / Grant/Research Support (Principal Investigator): Astra Zeneca.