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1. Introduction
2. High and low affinity Fc receptors
3. Fc receptor family
4. FcgammaRIIb: the inhibitory FcR
5. FcgammaRIIb on macrophages
6. FcgammaRIIb on B-cells
7. Crosslinking of FcgammaRII kill plasma cells
8. FcgammaRII acting as immune "brake"
9. Effects on infection - Strep. pneumoniae
10. Strept. pneumoniae in FcgammaRIIb-/- mice
11. Balancing bacterial clearance and septic shock
12. Over-expression, autoimmunity and infection
13. Effects of increasing FcgammaRIIb expression
14. FcgammaRIIb transgenic B cells
15. FcgammaRIIb transgenic macrophages
16. T dependent and independent responses
17. FcgammaRIIb and collagen-induced arthritis
18. Overexpression of FcgammaRIIb prevents SLE
19. FcgammaRIIb expression on macrophages
20. Polymorphic variation in FcgammaRIIb
21. Systemic lupus erythematosus (1)
22. Systemic lupus erythematosus (2)
23. 10 genomic regions predispose to SLE
24. Clustering of susceptibility loci for autoimmunity
25. Fcgamma receptors in mouse and man
26. Potential SLE susceptibility genes in Sle1 interval
27. FcgammaRII promoter polymorphisms (1)
28. FcgammaRII promoter polymorphisms (2)
29. FcgammaRII promoter polymorphisms (3)
30. Promoter polymorphism group distribution
31. The ancestral haplotype
32. Genetic associations with SLE
33. How FcgammaRIIb polymorphism relates to SLE?
34. Does infection drive predisposition to autoimmunity
35. Why do SLE-associated polymorphisms persist
36. Prevalence of SLE and FcgammaRIIb
37. Distribution of the FcgammaRIIB T232 mutation
38. Reduced FcgRIIB function protects against malaria
39. Does FcgRIIb deficiency protect against malaria?
40. Reduced parasitaemia in FcgammaRIIb-/- mice
41. Less severe malaria in FcgammaRII deficient mice
42. Increased phagocytosis in FcgRIIb-/- macroph. (1)
43. Increased phagocytosis in FcgRIIb-/- macroph. (2)
44. Upregulation of CD86 in FcgRIIb-/- macrophages
45. Increased TNF-alpha in FcgammaRIIb-/- mice
46. Increased anti-malarial Abs in FcgRIIb-/- mice
47. Reduced FcgammaRIIB function protects people?
48. Phagocytosis of P.falciparum trophozoites
49. FcgRIIB T/T protects infants from severe malaria
50. FcgRIIB T/T protects from bacterial infection
51. FcgammaRIIb deficiency in mice
52. Fc receptors: linking innate and acquired immunity
53. Genetic loci associated with SLE
54. SLE pathogenesis
55. FcgammaR in patients with SLE
56. FcgammaRIIIb: an unusual Fcgamma receptor
57. FcgRIIIb CN correlates with surface expression
58. FcgammaRIIIb deleted/copied region (1)
59. FcgammaRIIIb deleted/copied region (2)
60. FcgR-independent function and FcgRIIIb CN
61. Neutrophils adhere to IgG coated slides
62. Neutrophil adhesion correlates with FcgRIIIb CN (1)
63. Neutrophil adhesion correlates with FcgRIIIb CN (2)
64. Immune complex uptake and FcgRIIIb CN (1)
65. Soluble FcgRIIIb correlates with copy number
66. FcgammaRIIIb is important in neutrophil
67. FcgRIIIb CN correlates with surface expression
68. Neutrophil adhesion correlates with FcgRIIIb CN (3)
69. Immune complex uptake and FcgRIIIb CN (2)
70. Association of FcgammaRIIIb CN with disease
71. Summary
72. Acknowledgements

Topics Covered

• High and low affinity Fc receptors
• FcgRIIb: the inhibitory FcR
• An immune "brake"
• Effects on infection
• Strep. Pneumoniae
• Over-expression and autoimmunity
• Polymorphic variation in FcgRIIb
• Does infection drive genetic predisposition to autoimmunity?
• An activatory receptor
• Copy number variation and function

Links

Series:

• Innate Immunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Smith, K.G.C. (2009, June 30). Fc receptors: linking innate and acquired immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/1292/.
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Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Ken G C Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.