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1. Introduction
2. What are virulence plasmids?
3. Why are they important?
4. Types of virulence plasmids
5. Virulence plasmids
6. Toxin plasmids
7. Metabolic plasmids
8. Adhesin plasmids
9. Other virulence plasmids
10. The anthrax toxin plasmids
11. Genetic organisation of pXO1
12. Role of pXO1 in virulence
13. Interaction with host cells
14. Genetic organisation of pXO2
15. Regulation of toxin genes
16. Clostridial toxin plasmids: Clostridium tetani
17. Clostridial toxin plasmids: Clostridium perfringens
18. The CPE plasmids
19. Conjugation locus of C. perfringens toxin plasmids
20. Metabolic plasmids to be discussed
21. Mycolactone biosynthesis and pMUM001
22. pMUM001: a blueprint for mycolactone synthesis
23. mls genes are modular
24. The pJM1 virulence plasmid of Vibrio anguillarum
25. Genetic map of pJM1
26. Adhesin plasmids to be discussed
27. Enterotoxigenic E. coli infections
28. Enteropathogenic E. coli infections
29. Genetic map of pB171
30. Linear virulence plasmids of Borrelia
31. DNA molecules of B. burgdorferi
32. Other virulence plasmids to be discussed
33. Shigella
34. Shigella invasion process
35. The entry region on Shigella virulence plasmids
36. Mode of action of T3SS
37. The Ipa proteins
38. Role of IpaA-C in Shigella entry
39. Other T3SS effectors
40. Other proteins encoded by virulence plasmid
41. Yersinia
42. Yop plasmids
43. Summary
44. Acknowledgements

Topics Covered

• Definition and importance of virulence plasmids
• Types of virulence plasmids
• Toxin plasmids
• The anthrax toxin plasmids
• Clostridial toxin plasmids
• Metabolic plasmids
• Mycolactone biosynthesis by Mycobacterium ulcerans
• Iron uptake by Vibrio anguillarum
• Adhesin plasmids
• Enterotoxigenic E. coli: CFA
• Enteropathogenic E. coli: BFP
• Linear plasmids of Borrelia
• Other virulence plasmids
• Shigella: type III secretion system, ipa genes
• Yersinia: type III secretion system, yop genes
• Bacillus anthracis is the causative agent of anthrax
• pXO1 encodes toxin and regulatory genes
• pXO2 encodes capsule and regulatory genes

Links

Series:

• Biology and Significance of Plasmids

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on January 28, 2008

Financial Disclosures

• Prof. Julian Rood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.