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1. Introduction
2. Adipose tissue (AT) general comments
3. In vitro methods
4. In vivo methods
5. AT regulation
6. AT components
7. Storage mobilization overview
8. Lipoprotein lipase (LPL) action
9. LPL in various conditions and fat deposits
10. Transcapillary flux of fatty acids ( FA)
11. Theoretical fate of fatty acids in a cell
12. Fat cell fatty acid uptake system
13. Fatty acid esterification and TAG synthesis
14. Lipid transfer between lipid droplets and the ER
15. Regulation of lipolysis and lipid mobilization
16. Action of lipases (ATGL, HSL and MGL)
17. Hormone sensitive lipase (HSL)
18. HSL and ATGL expression
19. HSL and ATGL in insulin resistant patients
20. HSL and ATGL before/after hypocaloric diet
21. Perilipin and ABHB5
22. Perilipin, HSL translocation
23. Perilipin, ABHD5 interactions
24. Epinephrine-induced lipolysis
25. Alpha2-adrenergic mediated effect
26. Distribution of beta and alpha2-receptors
27. Signalling pathways in the control of lipolysis
28. Visceral and subcutaneous lipolysis
29. Beta-adrenergic receptors polymorphisms
30. Natriuretic peptides (ANP, BNP, CNP)
31. Physiological role of atrial natriuretic peptides
32. Natriuretic peptides and lipolysis
33. Type A NP receptors (NPR-A) and ANP signalling
34. Signalling pathways: cAMP and cGMP cross-talk
35. Other lipolytic/antilipolytic pathways
36. Diagram of lipolysis human fat cell - summary
37. Sum-up physiological approaches
38. Epinephrine response normal /obese
39. Systemic NEFA release lean/obese
40. Hepatic NEFA delivery
41. Effects of intravenous atrial natriuretic peptide
42. Diagram of in situ microdialysis
43. Isoproterenol and microdialysis of sc AT
44. ANP effect on lipolysis and blood flow
45. Exercise-induced lipid mobilization
46. Lipid mobilization and alpha2-blockade
47. Lipid mobilization in trained patients
48. Lipid mobilization under beta-blockade
49. Role of ANP in lipid mobilization
50. Lipolysis perspectives
51. TAG perspectives and general conclusions

Topics Covered

• Experimental approaches for study of adipose tissue biology
• Lipoprotein lipase and triacylglycerol hydrolysis
• Fatty acid uptake by fat cells
• Triacylglycerol synthesis
• Lipid droplets
• Adipocyte lipases
• Lipid droplet proteins
• Catecholamine-induced lipolysis
• Catecholamine and insulin signalling pathways
• Natriuretic peptides
• Atrial natriuretic peptide and lipolysis
• Lipid mobilization in lean and obese patients
• In situ microdialysis and lipolysis exploration
• Exercise-induced lipid mobilization in lean and obese
• Role of catecholamines
• Alpha2-adrenergic responsiveness and obesity
• Natriuretic peptides and lipid mobilization

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on January 20, 2009

Financial Disclosures

• Dr. Max Lafontan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.