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1. Introduction
2. Viral dynamics in patients on antiretroviral drugs
3. A resting CD4+ T cell
4. Resting/activated/infected CD4+ T cells
5. NFkappaB sites in the HIV LTR
6. Establishment/maintenance of latent reservoir
7. Frequency of latently infected CD4+ T cells (1)
8. Residual viremia and blips - HAART patients (1)
9. Frequency of latently infected CD4+ T cells (2)
10. Dynamics of the latent pool
11. Archival WT/drug resistance in latent reservoir
12. HIV evolution
13. Persistence of drug resistant variants - example
14. Assay for latent HIV in viremic patients
15. Archived nevirapine resistance
16. Residual viremia and blips - HAART patients (2)
17. Analysis of residual viremia in HAART patients
18. Results of residual viremia analysis
19. Theories regarding the blips in HAART patients
20. Analysis of blips with frequent sampling
21. No new mutations during blips
22. Blips don't represent elevations in viremia
23. Additional source of residual viremia
24. Detection of predominant plasma sequence (1)
25. Detection of predominant plasma sequence (2)
26. Why wasn't this phenomenon seen before?
27. Predominant plasma clone (PPC)
28. Characteristics of the PPC
29. Hypothesis on the origin of the PPCs
30. PPC and stability of the latent reservoir
31. Latent reservoir is not replenished by replication
32. Conclusions

Topics Covered

• Viral dynamics in patients on antiretroviral drugs
• CD4+ T-cells
• Response of resting T-cells to AG
• Establishment and maintenance of a latent reservoir
• Dynamics of the latent pool
• HIV evolution
• HAART
• Residual viremia and blips on patients on HAART
• The nature of blips
• Blips do not represent clinically significant elevations in viremia
• Characteristics of the PPC
• The latent reservoir is not replenished by ongoing viral replication in patients on HAART

Links

Series:

• Retroviruses

Categories:

• Clinical Practice
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Siliciano, R. (2007, October 1). Viral reservoirs, latency and mechanisms of HIV persistence [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/514/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Robert Siliciano has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.