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Navigable Slide Index

1. Introduction
2. Acknowledgements
3. Haloarcula marismortui is not a human pathogen
4. Antibiotic - first definition
5. Antibiotic - a broader definition
6. Penicillin
7. Paradox
8. Antibiotic specificity problems
9. Differences between ribosomes sensitivity
10. Good news
11. Bad news
12. A complete 70S ribosome
13. Large subuint
14. A fifth active site at the large ribosimal subunit
15. Structures of anti-ribosomal antibiotics
16. Binding of puromycin in the large subunit
17. Binding of anisomycin in the large subunit
18. Binding of sparsomycin in the large subunit
19. Binding of blasticidin in the large subunit
20. Binding of tylosin in the large subunit
21. Large/small subunit antibiotics
22. Anisomycin binding to the A cleft
23. Anisomycin cause conformation change
24. Position of U2539
25. Macrolide antibiotics
26. Ribosome-antibiotic complexes
27. Resistance to macrolide antibiotic
28. Position 2099 identity is significant
29. Azithromycin
30. Differences in peptide length product
31. Textbook explanation

Topics Covered

• Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics?
• Introduction to ribosome structure
• Antibiotic binding sites cluster in the ribosome
• The source of the species specificity of antibiotics that interact with the A-site cleft
• How macrolides interact with the ribosome
• The structural consequences of mutations that make ribosomes resistant to macrolides
• The toxicity of macrolides is not well understood
• 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome

Links

Series:

• The Mechanisms of Ribosome Function

Categories:

• Biochemistry
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Moore, P. (2008, May 15). The interaction of antibiotics with the large ribosomal subunit from Haloarcula marismortui [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/811/.
Export Citation (RIS)

Publication History

• Published on May 15, 2008
• Archived on February 25, 2021

Financial Disclosures

• Prof. Peter Moore has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.