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1. Introduction
2. The problem
3. The limit to resolution of pedigree studies
4. Possible solution
5. Theory of two loci
6. Linkage equilibrium
7. Linkage disequilibrium
8. Linkage disequilibrium measures
9. No recombination: SNPs A and B mutations
10. No recombination: only three gametes
11. Genealogical interpretation of D'=1
12. Statistical significance of LD
13. Decay of LD over time
14. Linkage disequilibrium change and random drift
15. LD and recombination rate equilibrium relation
16. Linkage disequilibrium decays across a gene
17. Linkage disequilibrium is rare beyond 100 kb or so
18. The linkage disequilibrium beyond 500 Kb
19. LD means the sites are likely to be close together
20. LD patterns examination by testing all sites' pairs
21. Different human populations different levels of LD
22. The international HapMap project
23. LD decay across the genome HapMap
24. Heterogeneity of LD across the genome
25. Recombination hotspots can break LD blocks
26. Hotspots of recombination
27. Tag SNPs increase efficiency in studies
28. SNPs proportion in phase I HapMap with tag SNP
29. Using the HapMap website (1)
30. Using the HapMap website (2)
31. Using the HapMap website (3)
32. Macular degeneration and CFH
33. Age-related macular degeneration
34. Transformative technology
35. Design of GWAS
36. Ongoing GWAS studies
37. The wellcome trust case control consortium (1)
38. The wellcome trust case control consortium (2)
39. dbGaP
40. Etiology or prediction? Drugs or diagnostics?
41. Etiology
42. Use of ability to predict disease risk
43. One DNA test gets you your perfect vitamin pack
44. The future paradigm: the 4 P's

Topics Covered

• The problem in pedigree analysis
• A possible solution for the resolution limitations in pedigree analysis
• Theory of two loci
• Linkage equilibrium and disequilibrium
• Recombination events between SNPs
• Genealogical interpretation
• Statistical significance of LD
• The effect of random drift on linkage disequilibrium
• Variability of LD among different populations
• Heterogeneity of LD across the genome
• Hotspots of recombination
• Tag SNPs
• The HapMap website
• Design of GWAS
• Welcome Trust Case Control Consortium
• Etiology

Links

Series:

• Human Population Genetics I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Andrew Clark has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.