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1. Introduction
2. Odysseus Is Tempted by the Sirens
3. Role and importance of p53
4. The p53 family (1)
5. The p53 family (2)
6. The p53 gene
7. p73-/- show neural defects
8. p73 regulates neural differentiation
9. p73 in immunity (1)
10. p73 in immunity (2)
11. p73 in immunity and cancer
12. Incidence of p73 alterations in cancer
13. Involvement of p73 in DNA damage response
14. Cell cycle arrest and apoptosis by p53 and TAp73
15. TAp73 induces apoptosis, while DNp73 inhibits it
16. The identification of p73 pathway
17. p73 post-translational modifications
18. The various proteins involved in p73 pathway
19. Interacting proteins: WW proteins
20. Role of chemo / radiotherapy in p73 activation (1)
21. Example: transactivation of CD95 gene (1)
22. p73 synergize with chemotherapy
23. p73 in hepatoma cells
24. Example: transactivation of CD95 gene (2)
25. Inactivation of p73 in cancer
26. Interaction between p53 and p63/p73
27. The life of a cell
28. Underground map of cell city
29. Suicide bomb attack to cancer city
30. Role of chemo / radiotherapy in p73 activation (2)
31. TAp73 degradation (1)
32. TAp73 degradation (2)
33. Degradation of ITCH and DNp73 in DNA damage
34. Can we control p73 protein levels?
35. Role of PML in stabilizing TAp73 protein
36. Conclusion of p73 degradation
37. Interacting proteins:Bub1, Bub3
38. p73 in cell cycle control
39. Summary: p73
40. The p53 family (3)
41. Some effects of p63
42. TAp63 induces cell cycle arrest and apoptosis
43. p63-induced apoptosis and p63 degradation (1)
44. p63-induced apoptosis and p63 degradation (2)
45. Role of p63 in epidermis and human diseases (1)
46. Role of p63 in epidermis and human diseases (2)
47. Vibrissae
48. Tooth development and p63 (1)
49. Tooth development and p63 (2)
50. Tooth development and p63 (3)
51. Formation of the epidermis (1)
52. Formation of the epidermis (2)
53. What is the function of p63?
54. p63 Transcriptional targets
55. Summary: p63
56. Evolution of the p53 family
57. Timescale of p63/p73 research

Topics Covered

• The p53/p63/p73 family
• DNA damage elicits repair mechanisms involving the tumour suppressor gene p53 and the two newer members of the same family: p63 and p73
• The molecular events driven by DNA damage to elicit the function of p63/p73 and their transcriptional regulation
• The biological effect of p63/p73 in the immune and neural systems

Links

Series:

• Apoptosis

Categories:

• Cancer
• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Gerry Melino has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.