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1. Introducation
2. The dual role of mitochondria in life and death
3. Mitochondria: the Pandora's box
4. The mitochondrial apoptogenic factors
5. How does Pandora's box open?
6. Two fundamental questions
7. Bcl-2 family
8. Three dimensional structure
9. A hydrophobic pocket interacts with BH3 domains
10. TM domain occupies Bax hydrophobic pocket
11. Two functional classes of BH3-only proteins
12. Bax under resting conditions
13. Bax during apoptosis
14. How antiapoptotic proteins protect cells
15. Conclusion 1
16. Two fundamental questions
17. The PTP cytochrome c release model (1)
18. The permeability transition pore
19. The PTP cytochrome c release model (2)
20. Opening the PTP raises questions
21. What about VDAC?
22. Bax channel model for cytochrome c release
23. Bcl-2 and bacterial toxins are structuraly similar
24. Bax pores
25. Bax/VDAC channel model for cytochrom c release
26. Lipidic pores/protein-lipid complex model
27. Structure of phospholipids
28. Bax lipidic pores
29. Summary
30. The role of mitochondrial fission in apoptosis
31. Bax-induced mitochondrial fragmentation
32. Fusion and fission machineries
33. Mitochondrial fission in apoptosis
34. A different view on mitochondria
35. Loss of OPA1 function and mitochondrial fission
36. Mitochondrial fission and cytochrome c release
37. Perspectives

Topics Covered

• Cell death
• Apoptosis
• Mitochondria
• Mitochondrial membrane permeabilization
• Bcl-2
• Bax
• Permeability transition pore
• Cytochrome c
• Mechanistic explanations
• Cancer
• Degenerative diseases

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 31, 2021

Financial Disclosures

• Prof. Jean-Claude Martinou has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.