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1. Introduction
2. Pharmacogenetics
3. Pharmacogenomics
4. Pharmacogenetics: brief history
5. Specific examples to be considered
6. Debrisoquine (CYP2D6) polymorphism
7. Debrisoquine polymorphism: studies on phenotype
8. Cytochromes P450
9. Molecular basis of CYP2D6 polymorphism
10. Poor metabolism and CYP2D6 polymorphisms
11. Copy number variants in CYP2D6
12. Number of CYP2D6 genes and nortryptiline
13. Tamoxifen and CYP2D6
14. CYP2D6 and codeine
15. Ultrarapid metabolizers and codeine
16. CYP2C9
17. Functional effect of CYP2C9 alleles
18. Warfarin
19. Vitamin K cycle
20. CYP2C9 genotypes and warfarin
21. Warfarin dose requirement
22. Vitamin K epoxide reductase
23. VKORC1 polymorphisms (1)
24. VKORC1 polymorphisms (2)
25. CYP2C9/VKORC1 genotype warfarin dose
26. Warfarin and pharmacogenetics
27. Association study on warfarin dose requirement
28. Methyltransferases
29. Thiopurine S-methyltransferase (TPMT)
30. TPMT polymorphism (1)
31. TPMT polymorphism (2)
32. Idiosyncratic adverse drug reactions
33. Simvastatin myopathy
34. Flucloxacillin-induced liver injury
35. Summary
36. References

Topics Covered

• Definition and history
• CYP2D6 polymorphism
• Pharmacogenetics of warfarin
• Thiopurine methyltransferase
• Genetics susceptibility to adverse drug reactions

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Professor Ann Daly has no commercial/financial relationships to disclose.