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1. Introduction
2. Ca homeostasis
3. Ca uptake, respiration and phosphorylation
4. The energy-linked reaction of Ca with mitochondria
5. Ca accumulation and cation/anion balance
6. Ca transport and the chemiosmotic theory
7. Nernst equation
8. The Na/Ca exchanger (1)
9. The Na/Ca exchanger (2)
10. The Na/H exchanger
11. Steady state Ca transport vs. net uptake
12. Extramitochondrial Ca regulation in-vivo experiment
13. Regulation of free Ca levels by mitochondria (1)
14. Regulation of free Ca levels by mitochondria (2)
15. Distinct kinetics
16. Phosphate role in mitochondrial Ca regulation
17. Ca efflux in presence of phosphate
18. Kinetics of the Ca uniporter by infusion (1)
19. Kinetics of the Ca uniporter by infusion (2)
20. Kinetics of the Ca uniporter by infusion (3)
21. Basic principles of mitochondrial Ca transport
22. Mitochondria buffer physiological Ca loads
23. Ca efflux in presence of acetate
24. Formation of Ca-phosphate complex
25. Phosphate and the control of the efflux pathway
26. Ca role in intramitochondrial metabolism regulation
27. Mitochondrial free vs. total Ca concentrations
28. Ca in mitochondria: regulation vs. buffering
29. Why is Ca insoluble in mitochondrial matrix? (1)
30. Why is Ca insoluble in mitochondrial matrix? (2)
31. Matrix Ca solubility as a function of matrix pH
32. The permeability transition
33. The mitochondrial maximal Ca loading capacity
34. Key events associated with permeability transition
35. Effect of cyclosporin on Ca loading capacity
36. Effect of acetoacetate on permeability transition
37. Summary
38. Buck Institute for Age Research

Topics Covered

• The calcium uniporter
• Mitochondrial calcium efflux pathways
• Steady state and net uptake
• The regulation of cytoplasmic calcium by mitochondria
• The role of phosphate and the matrix calcium phosphate complex
• Uniporter kinetics
• The set-point concept
• Matrix dehydrogenase regulation by calcium
• The permeability transition

Links

Series:

• Mitochondrial Biogenesis

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. David Nicholls has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.