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1. Introduction
2. Mendelian vs. complex diseases (1)
3. Mendelian vs. complex diseases (2)
4. The genetic epidemiology of complex diseases (1)
5. Case example: asthma phenotype
6. The genetic epidemiology of asthma
7. Linkage regions and candidate genes
8. Southern California Children's Health Study
9. Exposure assessment
10. Effects of particulates on bronchitis
11. Familial aggregation of asthma
12. Familial aggregation/maternal smoking interaction
13. GSTM1, maternal smoking, and active asthma
14. Pathways in asthma
15. Oxidative stress
16. Determinants of oxidative stress
17. Conceptual model for oxidative stress pathway
18. Genes involved in oxidative stress
19. Oxidative stress pathways (1)
20. Oxidative stress pathways (2)
21. The genetic epidemiology of complex diseases (2)
22. USC colorectal polyps study
23. Other pathways for sporadic colorectal cancer (1)
24. Multivariate analyses of polyps data (1)
25. Polyps data: main effects
26. Polyps data: mEH x well done red meat interaction
27. Interactions in polyps data
28. Problems with these approaches
29. Multivariate analyses of polyps data (2)
30. Bayes model averaging (1)
31. Bayes model averaging (2)
32. Bayes factors
33. Graphical illustration
34. Hierarchical model
35. Bayes factors for models (1)
36. Bayes factors for models (2)
37. Bayes factors for terms averaging across models
38. Graphical illustration
39. Incorporation of "prior covariates"
40. Multivariate analyses of polyps data (3)
41. Conceptual model for HCA and PAH pathways
42. HCA pathway
43. PAH pathway
44. Mathematical representation (1)
45. Mathematical representation (2)
46. Graphical illustration (1)
47. Graphical illustration (2)
48. Genotype-phenotype relationship for one step
49. Details of one step
50. Models for individual metabolic rates
51. Toxicogenetic models
52. Intermediate metabolites
53. Nonlinear toxixokinetics
54. Markov chain Monte Carlo
55. Details of MCMC sampling
56. Convergence of interaction term
57. Contribution of smoking to PAH pathway (1)
58. Contribution of smoking to PAH pathway (2)
59. Contribution of smoking to PAH pathway (3)
60. Contribution of exposures to both pathways
61. Contribution of pathways to polyps risk
62. Genetic effect estimates
63. Simulation studies
64. Graphical illustration
65. Simulated vs. estimated beta
66. Simulated vs. estimated gamma
67. Simulated vs. estimated delta
68. Simulated vs. estimated omega
69. Simulated vs. estimated phi
70. Simulated vs. estimated psi
71. Limitations: biological
72. Limitations: statistical
73. Other pathways for sporadic colorectal cancer (2)
74. Folate pathways
75. Folate (DNA methylation) pathway (1)
76. Genes involved in folate (DNA methylation) pathway
77. Folate (DNA methylation) pathway (2)
78. Folate (DNA repair) pathway (1)
79. Genes involved in folate (DNA repair) pathway
80. Folate (DNA repair) pathway (2)
81. Combined folate pathways
82. Other pathways for sporadic colorectal cancer (3)
83. Bile acids pathways (1)
84. Bile acids pathways (2)
85. Genes involoved in bile acid reabsorption
86. Bile acids pathways (3)
87. Genes involved in bile acid degredation
88. Bile acids pathways (4)
89. Bile acids biosynthesis
90. The bigger picture
91. Conclusions
92. A cautionary comment

Topics Covered

• Case study: asthma
• Multiple environmental agents
• Polygenic factors
• Standard approaches: contingency tables and logistic regression methods
• Latest approaches: Bayesian model averaging and pharmacokinetic modelling
• Case study: colorectal cancer
• Taking account of prior knowledge
• The potential for application to other pathways
• Biological and statistical limitations

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Thomas, D. (2004, September 1). Bayesian approaches for modelling complex metabolic pathways [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/31/.
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Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Duncan Thomas has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.