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1. Introduction
2. Contents
3. Factors determining interindividual variability
4. Special problems (1)
5. Special problems (2)
6. Terminology and notation
7. Random mating proportions
8. Subjects on drug dose j with i copies of allele A
9. Numbers of responders to drug treatment
10. Hypotheses of interest
11. t statistic to determine N for a given power
12. Accounting for interactions
13. Null and alternative hypothesis
14. Normal approximation for t statistic (1)
15. Normal approximation for t statistic (2)
16. Simulating the t distribution (1)
17. Simulating the t distribution (2)
18. Simulating the t distribution (3)
19. Distribution of t under H0 and H1
20. Determining the number of tests
21. Notes on method
22. Effect of allele does not depend on dose (1)
23. Effect of allele does not depend on dose (2)
24. Additive-by-dose interaction
25. Dominant-by-dose interaction
26. Recessive-by-dose interaction
27. How many independent tests?
28. Coefficients and procedure (1)
29. Coefficients and procedure (2)
30. Example
31. Factors to Consider
32. Results (1)
33. Results (2)
34. Results (3)
35. Discussion (1)
36. Discussion (2)
37. Taking account of genotype effects
38. When is it better to stratify by genotype?
39. Dense genome screening
40. Effect of number of tests on sample size (1)
41. Effect of number of tests on sample size (2)
42. References

Topics Covered

• Notation and test statistic
• Sample size determination
• Determining the number of tests
• Example of binary response to a drug

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Elston, R. (2004, September 1). The study of candidate genes in drug trials - sample size considerations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/27/.
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Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Robert Elston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.