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1. Introduction
2. Koch's postulates (1882)
3. Case
4. Clostridium difficile (1)
5. Clindamycin associated colitis due to C. difficile
6. Clostridium difficile (2)
7. C. difficile and the gastrointestinal microbiota
8. "Community thinking"
9. How to study the gut microbiota?
10. 16S rRNA
11. Antibiotic-associated diarrhea (AAD)
12. Microbial ecology of AAD
13. Microbial community associated with AAD
14. The enterome and gastrointestinal homeostasis
15. C. difficile and antibiotic-associated diarrhea
16. Patients/clinical results
17. Microbial ecology: diversity
18. Collectors curves/rarefaction
19. Initial and recurrent C. difficile rarefaction
20. C. difficile colitis - microbial ecology insights
21. How microbes defend and define us
22. Resilience of gut microbial community structure
23. Microbial communities in mice
24. Microbial response to antibiotic stress (1)
25. Microbial response to antibiotic stress (2)
26. Microbial community diversity and antibiotics
27. C. difficile in model systems
28. C. difficile associated disease -a mouse model(1)
29. C. difficile associated disease -a mouse model(2)
30. Dissecting role of antibiotics
31. Two groups of C. difficile treated mice
32. A normal mouse colon
33. A colon from an animal affected by c. difficile (1)
34. An infected animal with a benign response
35. A colon from an animal affected by c. difficile (2)
36. Colon histopathology difference
37. Vero cell cytotoxin assay on tissue
38. C. difficile load in tissues
39. Differences in microbial communities
40. Cefoperazone treatment (1)
41. Cefoperazone treatment (2)
42. Microbial ecology in cefoperazone treated mice
43. Survival in cefoperazone treated mice
44. Model
45. Summary
46. Acknowledgements

Topics Covered

• C. difficile and the antibiotic-associated colitis
• Changes in the microbiota due to antibiotics predisposed to C. difficile infection
• Use of culture-independent techniques to study the gut microbiota
• Antibiotics can have reproducible effects on the gut microbiota
• Animal models and human studies provide insight into the role of the gut microbiota in mediating colonization resistance against C. difficile infection

Links

Series:

• Microbiota

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Young, V. (2011, September 27). The microbiota in the development of colitis due to Clostridium difficile infection [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/2096/.
Export Citation (RIS)

Publication History

• Published on September 27, 2011

Financial Disclosures

• Dr. Vincent Young has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.